Microneurographic analysis on age-related changes in sympathetic nerve

交感神经年龄相关变化的显微神经造影分析

• 批准号: 04670092
• 负责人: MANO Tadaaki
• 金额: $ 1.34万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670092/
• 关键词: sympathetic nerve activity; aging; microneurography; positional change; water immersion; sleep apnea; sweating; skin blood flow; 加齢; 筋交感神経活動; ニューログラム; 起立負荷; 水浸; 重力; 血圧調節; 圧受容器反射

In order to clarify the effect of aging on sympathetic nerve activity in humans, we recorded muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA) by applying microneurography from subjects of various age-groups, and analyzed the age-related changes of in MSNA and SSNA under different environmental conditions. We also anlyzed the effect of aging on gender difference of resting activity and responsiveness to orthostasis of MSNA.1. Effect of aging on resting activity and responsiveness to orthostasis of MSNA.Subjects were 41 Healthy men. The resting activity increased with advancing age, and a linear correlation was found between age and resting activity. The responsiveness to orthostasis decreased with advancing age, and an inverse correlation was observed between age and responsiveness. 2. Effect of aging on gender difference in resting activity and responsiveness to orthostasis of MSAN.Subjects were 40 men and 25 women(age : 21-25 years)for young group, a … More nd 8 men and 7 women(age : 65-78 years)for elderly. The gender difference in resting activity and responsiveness to orthostasis of MSNA observed in young groups disappeared in the elderly. 3. Effect of aging on MSNA suppression induced by water immersion. Subjects were 16 men aged 19 to 67 years. Suppression rate of MSNA induced by head-out water immersion was attenuated with advancing age. 4. MSNA response during sleep apnea in the elderly. Subjects were three elderly men. A remarked enhancement of MSNA was observed during sleep apnea accompanied with an elevation of systemic blood pressure. 5. Effect of aging on SSNA and effector response. The effector response to SSNA including sweating and vasoconstriction was reduced in 70-year-old man as compared with young subjects.MSNA plays an important role in regulation of blood pressure. The increased MSNA with advancing age may be associated with a rise in systemic arterial blood pressure in the elderly. The decreased responsiveness of MSNA to positional change or head-out water immersion with advancing age indicates a reduced neural regulation no compensatory mechanism against body fluid shift induced by these loads. SSNAplays an essential role in thermoregulation. The attenuated effector responses to SSNA suggest a reduced function of effector organs, e.g. sweet glands or presphincter of skin vessels and/or receptors in the effector organs. Less

为了阐明年龄对人类交感神经活动的影响，我们采用显微神经成像技术记录了不同年龄组受试者的肌肉交感神经活动（MSNA）和皮肤交感神经活动（SSNA），并分析了不同环境条件下MSNA和SSNA的增龄性变化。并分析了年龄对静息活动和体位反应性的性别差异的影响.年龄对静息活动和立位反应性MSNA的影响。静息活动随年龄增长而增加，年龄与静息活动呈线性相关。体位反应性随年龄增长而下降，年龄与反应性呈负相关。2.年龄对MSAN静息活动和直立反应性性别差异的影响青年组男40例，女25例，年龄21-25岁， ...更多信息 老年人：男8名，女7名（年龄：65-78岁）。在年轻组中观察到的静息活动和对MSNA直立性反应的性别差异在老年人中消失。3.老化对水浸诱导的MSNA抑制的影响。受试者为16名男性，年龄19至67岁。头外浸水引起的MSNA抑制率随年龄增长而减弱。4.老年人睡眠呼吸暂停时MSNA反应受试者为三名老年男性。在伴有全身血压升高的睡眠呼吸暂停期间观察到MSNA显著增强。5.衰老对SSNA和效应子应答的影响。70岁以上的老年人对SSNA的效应反应，包括出汗和血管收缩，均较年轻人减少，说明MSNA在血压调节中起重要作用。随着年龄的增长，MSNA的增加可能与老年人全身动脉血压的升高有关。随着年龄的增长，MSNA对位置变化或头伸出水浸泡的反应性降低，表明神经调节减少，对这些负荷引起的体液转移没有补偿机制。SSNA在体温调节中起重要作用。对SSNA的减弱的效应器应答表明效应器器官（例如，皮肤血管的汗腺或前括约肌和/或效应器器官中的受体）的功能降低。少

项目成果

Mano,Tadaaki: "Microneurographic analysis of sympathetic nerve activity in humans under simulated microgravity." Proceedings of the 1st International Workshop,“Space and Underwater Neurology",Messina-Taormina,Italy. 1-5 (1992)

Mano, Tadaaki：“模拟微重力下人类交感神经活动的显微神经学分析。”第一届国际研讨会论文集，“空间和水下神经学”，意大利墨西拿-陶尔米纳 1-5 (1992)。

Mano, T.: "Ch.6, "Physiology of the Elderly, -Adaptation to Environment-"(in Japanese)" Committee on Nagoya University Open Seminar ed., Longevity, Daiichi Houki. 53-67 (1993)

Mano, T.：“第 6 章，“老年人的生理学，-环境适应-”（日语）”名古屋大学公开研讨会委员会编辑，长寿，Daiichi Houki。

岩瀬敏: "加齢に伴う循環動態の変化." 自律神経. 30. 228-233 (1993)

Satoshi Iwase：“与衰老相关的血流动力学变化。” 30. 228-233 (1993)。

Iwase,Satoshi: "Age-related changes and gender difference in sympathetic outflow to muscles against gravitational stress in humans." In:Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992,ed by Matsui N,Seo H.249-258 (1992)

Iwase Satoshi：“人类对抗重力压力的肌肉交感神经流出与年龄相关的变化和性别差异。”

Miwa, C., Iwase, S., Mano, T., Saito, M., Sugiyama, Y., Suzuki, H.: "Age-related changes in sympathetic outflow to muscles in humans during head-out water immersion. (in Japanese)" The Autonomic Nervous System. 30. 16-23 (1993)

Miwa, C.、Iwase, S.、Mano, T.、Saito, M.、Sugiyama, Y.、Suzuki, H.：“在头部浸水期间，人类肌肉交感神经流出的年龄相关变化。（