X-ray Photoelectron Spectroscopy (XPS)

X 射线光电子能谱 (XPS)

• 批准号: 441723937
• 金额: --
• 依托单位: Universität Rostock
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/441723937?language=en
• 关键词: ray; Photoelectron; Spectroscopy; XPS

Surfaces, their structure and chemical composition, play a major role in implant development with regard to biocompatibility, in particular implant-tissue interaction. By means of X-ray photoelectron spectroscopy (XPS), layer analysis in the height range of few nanometers can be performed on conductive materials, as well as on non-conductive materials such as polymers. Ion beam etching also makes depth profile analysis accessible and allows for the investigation of surface degradation, corrosion as well as determination of laminations and for the analysis of diffusion effects between two layers. Thus it is possible to obtain not only the distribution of elements, but also characterize surface modifications for the development of innovative implant platforms, for example the differentiation and quantification of hydroxyl and carbonyl groups after treatment of a material with oxygen plasma. This is relevant as the types of functional groups determine the method and the yield of the binding of pharmaceutically active compounds, and also have a direct effect on biocompatibility. In addition, the expected results allow for the establishment of precise modification processes, e.g. for the loading of drug molecules, as well as predictions on the stability of surface modifications.

表面、其结构和化学成分在植入物开发中的生物相容性方面发挥着重要作用，特别是植入物-组织相互作用。借助X射线光电子能谱（XPS），可以对导电材料以及聚合物等非导电材料进行几纳米高度范围内的层分析。离子束蚀刻还可以进行深度轮廓分析，并允许调查表面退化、腐蚀以及确定层压和分析两层之间的扩散效应。因此，不仅可以获得元素的分布，而且还可以表征用于开发创新植入平台的表面改性，例如在用氧等离子体处理材料后对羟基和羰基进行区分和定量。这是相关的，因为官能团的类型决定了药物活性化合物结合的方法和产率，并且还对生物相容性具有直接影响。此外，预期的结果允许建立精确的修饰过程，例如用于药物分子的加载，以及对表面修饰的稳定性的预测。