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Studies on Metabolism of Triclosan, a Disinfectant, as Medical Waste by Activated Sludges

活性污泥代谢消毒剂三氯生作为医疗废物的研究

基本信息

批准号：
04670329
负责人：
MATSUSHIMA Hajime
金额：
$ 1.28万
依托单位：
Hamamatsu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

项目摘要

Effects of triclosan (2,4,4'-Trichloro-2'-hydroxydiphenyl ether) on activated sludges were investigated using an oxygen up-take method. As the results, the maximum non-reactive concentration of this disinfectant was 20 mg/l, and its inhibition rate 50 % concentration was 50 mg/l. The toxicity of triclosan has stronger than those of other disinfectants, except the maximum non-reactive concentration of hexachlorophene (6 mg/l).Triclosan concentrations in medical waste water from Hamamatsu University School of Medicine were within the range of several hundred ng/l to several mug/l. We have already reported that the concentrations of chlorhexidine and benzethonium chloride in medical waste water discharged from our university were several hundred mug/l and several mg/l, respectively. It is clear that the values of this compound are remarkably lower than both disinfectants. The results are reflected that the used amount of this compound is lower compared with those of others.The concentrations of triclosan in raw water, biological treatment waster and final treatment water from the medical waste water treatment plant of our university were not also detected by new mass fragmentography developed. It can be presumed that this compound is adsorbed or decomposed by activated sludges.The metabolism of triclosan on activated sludges is presupposed as follows ; (1) the estification or conjugation of 2'-hydroxy radical, (2) the peroxidation of benzene rings, and the hydroxylation, (3) dechlorination of 2,4,4'-chlorine. The metabolites of triclosan were found to be methyl estification of 2'-hydroxy radical and any one dechlorination of 2,4,4'-chlorine by high pressure liquid chromatography and mass fragmentography.

采用吸氧法研究了三氯生(2，4，4‘-三氯-2’-羟基二苯醚)对活性污泥的影响。结果，该消毒剂的最大无活性浓度为20 mg/L，抑制率50%浓度为50 mg/L。除六氯酚最大无活性浓度(6 mg/L)外，三氯生的毒性均强于其他消毒剂。滨松大学医学部医疗废水中三氯生的浓度范围为几百ng/L至几杯/L。我们已报道，我校排放的医疗废水中洗必泰和苯乙氯铵的浓度分别为数百mg/L和几mg/L。很明显，该化合物的数值明显低于这两种消毒剂。结果表明，与其他化合物相比，该化合物的使用量较低。我校医疗废水处理厂的原水、生物处理废水和最终处理水中的三氯生浓度也没有检测到。三氯生在活性污泥上的代谢假定如下：(1)2‘-羟基自由基的酯化或共轭；(2)苯环的过氧化；(3)2，4，4’-氯的脱氯。三氯生的代谢产物是2‘-羟基自由基甲基化和2，4，4’-氯的任意一次脱氯。