Morphological and hemodynamic changes of the fetal heart : chronological evaluation from fetus to newborn

胎儿心脏的形态和血流动力学变化：从胎儿到新生儿的时间顺序评估

• 批准号: 04670627
• 负责人: KATO Hirohisa
• 金额: $ 1.41万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670627/
• 关键词: fetal echocardiography; intrauterine diagnosis; fetal arrhythmia; intrauterine treatment; fetal pharmacokinetics

1.Prenatal diagnosis of fetal stuctural heart anomaly and fetal arrhythmia Fetal echocardiography was performed for 1080 cases. Thirty-four cases of structural heart anomaly and 44 cases of fetal arrhythmia was diagnosed and managed perinatal period.2.Fetal arrhythmia and fetal therapy.(1)In fetal bradycardia group, fetal therapy was performed in 3 cases but all failed.(2)In fetal tachycardia group, digoxin or verapamil was administered transplacentally in 5 cases, and 4 was successfully treated.3.Structural heart anomaly ; prenatal diagnosis and perinatal management.(1)In the tricuspid valve dysplasia case, we could proved prenatal development of pulmonary valve stenosis and functional pulmonary valve obstruction.(2)Digoxin was administered transplacentally for fetal hydrops caused by CHD, and successfully teated.4.Transplacental pharmacokinetics of digoxin and flecainide in pregnant rabbits and fetuses.(1)Although the placental transfer of digoxin occurred immediately, equilibrium between maternal and fetal serum consentration.(2)Flecainide was transferred the placenta rapidly and equilibrium between maternal and fetal serum concentration occurred very fast.

1.胎儿心脏结构异常及心律失常的产前诊断本文对1080例胎儿进行了超声心动图检查。对34例心脏结构异常和44例胎儿心律失常进行围产期诊断和处理。2.胎儿心律失常和胎儿治疗。(1)In胎儿心动过缓组，3例进行了胎儿治疗，但均失败。(2)In胎儿心动过速组5例经胎盘给予地高辛或维拉帕米，4例成功。3.心脏结构异常;产前诊断及围生期处理。(1)In三尖瓣发育不良1例，可证实产前有肺动脉瓣狭窄及功能性肺动脉瓣阻塞。（2）地高辛经胎盘给药治疗CHD引起的胎儿水肿，并取得成功。（4）地高辛和氟卡尼在孕兔和胎儿体内的经胎盘药代动力学。（1）地高辛经胎盘转运虽立即发生，但母胎血清浓度平衡。（2）氟卡尼经胎盘转运迅速，母胎血药浓度很快达到平衡。

项目成果

Y Yamashita,T Abe,N Ohara,T Maruoka,O Toyoda,O Inoue,K Kojima,H Kato: "Successful treatment of neonatal aneurysmal dilatation of the vein of Galen:,the role of prenatal diagnosis and trans-arterial embolization" Neuroradiology. 34. 457-459 (1992)

Y Yamashita，T Abe，N Ohara，T Maruoka，O Toyoda，O Inoue，K Kojima，H Kato：“成功治疗新生儿盖伦静脉动脉瘤扩张：产前诊断和经动脉栓塞的作用”神经放射学

前野 泰樹,加藤 裕久: "胎児不整脈の薬物治療" 周産期医学. 22. 761-765 (1992)

Taiki Maeno、Hirohisa Kato：“胎儿心律失常的药物治疗”围产期医学。22. 761-765 (1992)

Hirohisa Kato Noriko Rikitake On Toyoda: "Fetal echocardiography:New insight into fetal Cardology-A review" Journal of Cardiology. 18. 507-522 (1988)

Hirohisa Kato Noriko Rikitake On Toyoda：“胎儿超声心动图：胎儿心脏病学的新见解 - 综述”心脏病学杂志。

N Rikitake,H Kato,On Toyoda,K Suzuki,O Inoue,T Mikajima,T Akagi,T Miyake,T Matsunaga,J Ishimatsu: "Fetal Echocardiography:Recognition and Intrauterine Treatment of Fetal Cardiac Problems and Prenatal Diagnosis of Congenital Heart Disease" The Kurume Medic

N Rikitake、H Kato、On Toyoda、K Suzuki、O Inoue、T Mikajima、T Akagi、T Miyake、T Matsunaga、J Ishimatsu：“胎儿超声心动图：胎儿心脏问题的识别和宫内治疗以及先天性心脏病的产前诊断”

Y Yamashita.T Abe,N Ohara,T Maruoka,O Toyoda,O Inoue,K Koiima,H Kato: "Successful treatment of neonatal aneurysmal dilatation of the vein of Galen:the role of prenatal diagnosis and trans-arterial embolization" Neuroradiology. 34. 457-459 (1992)

Y Yamashita.T Abe，N Ohara，T Maruoka，O Toyoda，O Inoue，K Koiima，H Kato：“成功治疗新生儿盖伦静脉动脉瘤扩张：产前诊断和经动脉栓塞的作用”神经放射学。