Morphological and hemodynamic changes of the fetal heart : chronological evaluation from fetus to newborn

1.对1080例胎儿心脏结构异常和胎儿心律失常进行了胎儿超声心动图检查。对34例胎儿心脏结构异常和44例围产期胎儿心律失常进行了诊断和处理。2.胎儿心律失常与胎儿治疗：(1)胎儿心动过缓组3例胎儿治疗失败，(2)胎儿心动过速组经胎盘给予地高辛或维拉帕米治疗5例，成功4例。产前诊断和围产期处理：(1)在三尖瓣发育不良的病例中，我们可以证实产前发生了肺动脉瓣狭窄和功能性肺动脉瓣梗阻。(2)地高辛用于治疗CHD引起的胎儿积水，并成功地应用于胎盘。4.地高辛和氟卡胺在妊娠兔和胎儿体内的胎盘药代动力学。(1)虽然地高辛在胎盘中的转运立即发生，但母儿血清浓度平衡。(2)氟卡胺迅速转移到胎盘，母儿血药浓度迅速达到平衡。

1.Prenatal diagnosis of fetal stuctural heart anomaly and fetal arrhythmia Fetal echocardiography was performed for 1080 cases. Thirty-four cases of structural heart anomaly and 44 cases of fetal arrhythmia was diagnosed and managed perinatal period.2.Fetal arrhythmia and fetal therapy.(1)In fetal bradycardia group, fetal therapy was performed in 3 cases but all failed.(2)In fetal tachycardia group, digoxin or verapamil was administered transplacentally in 5 cases, and 4 was successfully treated.3.Structural heart anomaly ; prenatal diagnosis and perinatal management.(1)In the tricuspid valve dysplasia case, we could proved prenatal development of pulmonary valve stenosis and functional pulmonary valve obstruction.(2)Digoxin was administered transplacentally for fetal hydrops caused by CHD, and successfully teated.4.Transplacental pharmacokinetics of digoxin and flecainide in pregnant rabbits and fetuses.(1)Although the placental transfer of digoxin occurred immediately, equilibrium between maternal and fetal serum consentration.(2)Flecainide was transferred the placenta rapidly and equilibrium between maternal and fetal serum concentration occurred very fast.