Development of the new transctaneous occlusion system for patent ductus arteriosus

1.动脉导管未闭三维模型的建立应用含钡硅橡胶制作动脉导管未闭的解剖模型。最后制作了最小直径为2 mm、3 mm和3 mm的3种典型动脉导管。利用这些管型，进行了以下研究。研制了一种新的导管闭塞系统。并制作了不同形状的线圈。根据不同的不锈钢丝直径和不同的线圈圈数，对线圈的变形、耐久性能和柔韧性进行了评价。最后，采用0.038英寸线材制成的线圈，获得了合适的耐久性和柔韧性。此外，我们还发现，当动脉导管的最小直径大于3.0 mm时，同时双圈技术是非常有效的。因此，我们开发了一种4Fr端孔多用途导管，用于这种双或三弹簧圈技术。动脉导管未闭弹簧圈封堵后封堵机制的评估。在动脉导管未闭导管闭合后6个月至1年，进行血管内回声研究。利用这项技术，可以很好地确定种植体周围的内异质化。这些发现表明，这种疾病的线圈闭塞的长期结果将是良好的结果。

1.Establishment of three dimensional model of patent ductus arteriosusUsing 30 post mortarn cardiac specimens, which complicated with patent ductus arteriosus, anatomical model of ductus was made by barium contented silicone rubber. Finally, three types of typical ductus arteriosus were made, such as 2,3 and 3 mm of minimum diameter of ductus. Using these casts, following studies were performed.Development of a new system for ductus occlusionSelection of metal materials for the new system were studied. and formation of different shapes of coils were manufactured. Deformation, endurance and flexibility of coils were evaluated in terms of different diameter of stainless wires, and different number of coil loops. Finally, appropriate endurance and flexibility of coils were obtained in case of the coils ware made by 0.038 inch wire. Additionally, we found that simultaneous double coil technique is very effective when the minimum diameter of ductus arteriosus was more than 3.0mm. Thus, we developed a 4 Fr end-hole multipurpose catheter for this double or triple coil technique.Evaluation of occlusion mechanisms after coil occlusion of patent ductus arteriosus. At6 months to 1 years after the catheter closure of patent ductus arteriosus, intravascular echo studies were performed. Using this technique, endotherializaion around the implanted could be defined well. Such findings revealed that the long-term outcome of coil occlusion of this disease would be good outcome.