Development of the new transctaneous occlusion system for patent ductus arteriosus

1.动脉导管未闭三维模型的建立采用30例合并动脉导管未闭的死后心脏标本，用含钡硅橡胶制作动脉导管解剖模型。最后制作了3种典型的动脉导管，如导管最小直径为2、3和3mm。利用这些模型进行了以下研究：一种新型导管封堵系统的研制研究了新型导管封堵系统金属材料的选择。并形成不同形状的线圈。根据不同直径的不锈钢丝和不同数量的弹簧圈，评价弹簧圈的变形、耐久性和柔韧性。最后，当线圈由0.038英寸钢丝制成时，线圈具有适当的耐久性和柔韧性。此外，我们发现当动脉导管最小直径大于3.0mm时，同时双线圈技术非常有效。因此，我们开发了一种4 Fr端孔多功能导管，用于这种双或三线圈技术。动脉导管未闭线圈闭塞后闭塞机制的评价。在动脉导管未闭导管闭合后6个月至1年，进行血管内回声检查。利用该技术，可以很好地确定植入物周围的内皮化。这些结果表明，这种疾病的弹簧圈闭塞的长期结局将是良好的结局。

1.Establishment of three dimensional model of patent ductus arteriosusUsing 30 post mortarn cardiac specimens, which complicated with patent ductus arteriosus, anatomical model of ductus was made by barium contented silicone rubber. Finally, three types of typical ductus arteriosus were made, such as 2,3 and 3 mm of minimum diameter of ductus. Using these casts, following studies were performed.Development of a new system for ductus occlusionSelection of metal materials for the new system were studied. and formation of different shapes of coils were manufactured. Deformation, endurance and flexibility of coils were evaluated in terms of different diameter of stainless wires, and different number of coil loops. Finally, appropriate endurance and flexibility of coils were obtained in case of the coils ware made by 0.038 inch wire. Additionally, we found that simultaneous double coil technique is very effective when the minimum diameter of ductus arteriosus was more than 3.0mm. Thus, we developed a 4 Fr end-hole multipurpose catheter for this double or triple coil technique.Evaluation of occlusion mechanisms after coil occlusion of patent ductus arteriosus. At6 months to 1 years after the catheter closure of patent ductus arteriosus, intravascular echo studies were performed. Using this technique, endotherializaion around the implanted could be defined well. Such findings revealed that the long-term outcome of coil occlusion of this disease would be good outcome.