Development of novel drugs to control oral biofilms towards clinical application

香菇提取物对变形链球菌生物膜形成有抑制作用，且呈剂量依赖性。相比之下，提取物不影响嗜热菌细胞的生长。据认为，有效成分的产生具有时间依赖性。此外，还阐明了S.香菇提取物对变形杆菌糖基转移酶有抑制作用。这些结果揭示了香菇和相关物种的有效物质可能在临床上可用作减少龋齿的药物的可能性。

The Shiitake extracts inhibited the biofilm formation of Streptococcus mutans in dose dependent manner. By contrast, the extracts did not affect the growth of the planktonic bacterial cells. It was suggested that the effective components are produced in time dependent manner. In addition, it was elucidated that the enzymatic activity of S. mutans glycosyltransferases was inhibited by the Shiitake extracts. These results revealed the possibility that the effective materials from Shiitake and related species might be clinically available as drugs to reduce dental caries.