Development of novel drugs to control oral biofilms towards clinical application

香菇提取物对变形链球菌生物被膜形成的抑制作用呈剂量依赖关系。相比之下，这些提取物并不影响浮游细菌细胞的生长。结果表明，有效成分的产生与时间有关。此外，香菇提取物对变形链球菌糖基转移酶的活性也有抑制作用。这些结果表明，香菇及其近缘种的有效物质有可能作为减少龋病的药物应用于临床。

The Shiitake extracts inhibited the biofilm formation of Streptococcus mutans in dose dependent manner. By contrast, the extracts did not affect the growth of the planktonic bacterial cells. It was suggested that the effective components are produced in time dependent manner. In addition, it was elucidated that the enzymatic activity of S. mutans glycosyltransferases was inhibited by the Shiitake extracts. These results revealed the possibility that the effective materials from Shiitake and related species might be clinically available as drugs to reduce dental caries.