Experimental study on impairment of reticuloendothelial system of the contralateral lobe of the liver in localized cholangitis.
局限性胆管炎对侧肝叶网状内皮系统损伤的实验研究。
基本信息
- 批准号:04670760
- 负责人:
- 金额:$ 0.51万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C).
- 财政年份:1992
- 资助国家:日本
- 起止时间:1992 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Based on our experiences that localized cholangitis in the liver affected the function of whole liver, we studied the influences of localized cholangitis to the contralateral lobe of the liver in dog.Eight adult dogs were involved in this study. Of these, five were entered in the group of localized cholangitis (Group A), and three were entered in control group (Group B). The bile duct of B3 was cannulated and the hepatic artery and portal vein to that segment was prepared for tentative occlusion with vessel loops. Lipid Emulsion Test (LET) was employed to estimate the function of reticulo-endothelial system (RES). For estimating the function of RES other than the area baring cholangitis, blood vessels were occluded prior to LET.Just after the operation, the first LET was performed, and the second and the third LET were performed one and two weeks after the operation, respectively. After the second LET,3 mg of endotoxin in 0.1 ml of saline was injected into the B3 through a catheter in Group A.Same amount of saline alone was injected into the B3 in Group B.After the third LET,dogs were sacrificed and the liver was investigated microscopically.In Group A,disappearance rate of lipid in the serum at the third LET was significantly decreased compared to the second LET,thus the impairment of RES in contralateral lobe of the liver caused by localized cholangitis was clarified. However, liver function tests other than alkaline phosphatase and gamma glutamyl transpeptidase was not affected by such burden as cholangitis. Although infiltration of inflammatory cells in the portal triad, stenotic change of bile ducts and fibrotic change was seen in the lobe of cholangitis, contralateral lobe was found to have no specific change. In Group B,disappearance rate of lipid in the serum was no difference between the second and the third LET.In conclusion, localized cholangitis in dog impaired the function of RES in the contralatelal lobe.
根据我们对肝脏局限性胆管炎影响全肝功能的经验,我们研究了局限性胆管炎对犬对侧肝叶的影响。其中局限性胆管炎组(A组)5例,对照组(B组)3例。B3胆管插管,肝动脉和门静脉通向B3段,试探性阻断血管环。采用脂质乳化法(LET)评价网状内皮系统(RES)的功能。术前结扎血管,术后即刻进行第1次LET,术后1周和2周分别进行第2次和第3次LET,以评价除胆管炎部位外的RES功能。第二次LET后,A组B3经导管注入0.1ml生理盐水中加入内毒素3 mg,B组B3内注入等量生理盐水,第三次LET后处死犬,取肝脏进行光镜观察,A组第三次LET时血清脂质消失率较第二次LET明显降低,从而明确了局限性胆管炎对肝组织的损害。然而,除碱性磷酸酶和γ-谷氨酰转肽酶以外的肝功能检查不受胆管炎等负担的影响。胆管炎侧叶虽有炎性细胞浸润、胆管狭窄和纤维化改变,但对侧叶无特异性改变。B组第二、三叶血清脂质消失率差异无统计学意义。结论:犬局限性胆管炎损害对侧叶RES功能。
项目成果
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