HYBRID ASSISTED CIRCULATION DEVICE DRIVEN BY AUTOSKELETAL MUSCLE

由自骨骼肌驱动的混合辅助循环装置

• 批准号: 04670833
• 负责人: KONDO Jiro
• 金额: $ 0.83万
• 依托单位: Yokohama City Univ.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670833/
• 关键词: cardiomyoplasty; skeletal muscle; muscle contraction; assisted circulation device

Since the initiation of our basic research in 1987 relating to cardiomyoplasty, fundamental data concerning acquisition of resistance to fatigue by skeletal muscle, including transformation, improvement in hemodynamics, and output, have been accumulated.Based on this information, experiments were performed to elucidate the basic capacity of skeletal muscle and to develop an experimental assisted circulation device driven by skeletal muscle.Using a method of vascular template, changes in blood circulation in the latissimus dorsi which were devascularized except for the thoracodorsal vessels were analyzed in dogs. Development of arterioles from the region in control of the thoracodorsal vessels to the devascularized region led to restoration of blood circulation. This finding may be important to overcome the problem of muscular fatigue.In an acute experiment using adult dogs, an assisted circulation device driven by the latissimus dorsi was produced, and its output characteristics were determined. The results suggest that the latissimus dorsi has sufficient output to assist cardiac function for a short period of time, while sustained supply of sufficient output was impossible because of fatigue. Although the number of dogs used was too small to obtain valid results, the latissimus dorsi may have sufficient output to drive a pump for assistance of cardiac function.Future studies are needed to study the following : 1) What type of pump is required for efficient utilization of the output from the latissimus dorsi? ; and 2) Does the pretreated latissimus dorsi (vascular delay and preconditioning) results in fatigue resistance leading to prolonged operation of the pump?

自1987年开始有关心肌成形术的基础研究以来，已经积累了有关骨骼肌获得抗疲劳性的基础数据，包括转化、血流动力学的改善和输出量。基于这些信息，进行了实验以阐明骨骼肌的基本能力，并开发了由骨骼肌驱动的实验性辅助循环装置。 模板，分析了狗背阔肌的血液循环变化，背阔肌除胸背血管外均已断流。从控制胸背血管的区域到断血管区域的小动脉发育导致血液循环的恢复。这一发现对于克服肌肉疲劳问题可能具有重要意义。 在一项使用成年犬的急性实验中，制作了一种由背阔肌驱动的辅助循环装置，并测定​​了其输出特性。结果表明，背阔肌在短时间内有足够的输出来辅助心脏功能，但由于疲劳而无法持续提供足够的输出。尽管使用的狗数量太少而无法获得有效结果，但背阔肌可能有足够的输出来驱动泵以辅助心脏功能。未来的研究需要研究以下内容：1）需要什么类型的泵才能有效利用背阔肌的输出？ ; 2) 预处理的背阔肌（血管延迟和预处理）是否会导致抗疲劳性，从而导致泵长时间运行？