HYBRID ASSISTED CIRCULATION DEVICE DRIVEN BY AUTOSKELETAL MUSCLE

从1987年开始进行心肌成形术的基础研究以来，积累了关于骨骼肌获得抗疲劳性的基本数据，包括转化、血流动力学改善和输出。基于这些信息，本实验旨在阐明骨骼肌的基本功能，并研制一种由骨骼肌驱动的实验性辅助循环装置在血管模板的基础上，分析了犬背阔肌中除胸背血管外的血管被切断后的血液循环变化。从控制胸背血管的区域到断流区域的小动脉的发育导致血液循环的恢复。这一发现可能是重要的，以克服肌肉疲劳的问题。在急性实验中使用成年狗，辅助循环装置驱动的背阔肌，并确定其输出特性。结果表明，背阔肌有足够的输出，以协助心脏功能的一个短的时间内，而持续供应足够的输出是不可能的，因为疲劳。虽然使用的狗的数量太少，无法获得有效的结果，背阔肌可能有足够的输出，以驱动一个泵，以帮助心脏功能。未来的研究需要研究以下问题：1）什么类型的泵是需要有效利用的输出从背阔肌？预处理背阔肌（血管延迟和预处理）是否会导致抗疲劳性，从而延长泵的运行时间？

Since the initiation of our basic research in 1987 relating to cardiomyoplasty, fundamental data concerning acquisition of resistance to fatigue by skeletal muscle, including transformation, improvement in hemodynamics, and output, have been accumulated.Based on this information, experiments were performed to elucidate the basic capacity of skeletal muscle and to develop an experimental assisted circulation device driven by skeletal muscle.Using a method of vascular template, changes in blood circulation in the latissimus dorsi which were devascularized except for the thoracodorsal vessels were analyzed in dogs. Development of arterioles from the region in control of the thoracodorsal vessels to the devascularized region led to restoration of blood circulation. This finding may be important to overcome the problem of muscular fatigue.In an acute experiment using adult dogs, an assisted circulation device driven by the latissimus dorsi was produced, and its output characteristics were determined. The results suggest that the latissimus dorsi has sufficient output to assist cardiac function for a short period of time, while sustained supply of sufficient output was impossible because of fatigue. Although the number of dogs used was too small to obtain valid results, the latissimus dorsi may have sufficient output to drive a pump for assistance of cardiac function.Future studies are needed to study the following : 1) What type of pump is required for efficient utilization of the output from the latissimus dorsi? ; and 2) Does the pretreated latissimus dorsi (vascular delay and preconditioning) results in fatigue resistance leading to prolonged operation of the pump?