A study on photoradiation therapy on malignant glioma using Argon laser

采用波长为514.5nm的氩激光对大鼠C6脑胶质瘤模型和临床患者进行了光辐射治疗（PDT）的研究，血卟啉衍生物（HpD）对大鼠C6脑胶质瘤模型的研究结果表明，PRT对肿瘤的作用既包括对肿瘤细胞的损伤，也包括对肿瘤血管内皮的损伤，这些是导致肿瘤破坏的主要机制。我们从6例用HpD治疗的患者和1例最近用Photofrin II治疗的患者中获得了临床结果。在前一组中，PRT对恶性胶质瘤没有明显的效果，在肿瘤复发的时间间隔和生存期方面。然而，对于后一个病人，似乎有一个显着的效果PRT，表明MRI和CT，并在第二次手术中获得的标本的组织病理学结果。6例患者治疗方法的差异是（1）使用Photfrin II，（2）更高功率的激光，（3）肉眼下肿瘤全切除。临床结果提示，一种新的光敏物质Photofrin Ⅱ可能是PRT治疗恶性胶质瘤的有效药物，这些结果还需进一步研究证实。

We studied on the effects of photoradiation therapy(PRT) using the Argon laser tuned to 514.5 nm in the rat C6 glioma model and clinical patients.Our results from the study of the rat C6 glioma model with hematoporphyrin derivative(HpD) indicate that the effects of PRT on tumors include both tumor cell damage and endothelial damages of tumor vessels, and these are the main mechanisms causing tumor destruction.We have obtained clinical results from 6 patients treated with HpD and one patient most recently treated with Photofrin II.In the former group, there was no marked effect of PRT on malignant gliomas, in terms of time interval to tumor relapse and survival period. However, for the latter patient, there seems to have been a remarkable effect of PRT, indicated by MRI and CT, and histopathological findings of the specimen obtained during the second surgery. Differences of treatmant method from the 6 patients were (1)the use of Photfrin II, (2)higher power of laser, and (3)macroscopically total removal of tumor. Clinical results suggest that a new photosensitive substance, Photofrin II, may be a potent drug for treatmant of malignant glioma by means of PRT.Further investigations should be necessary to confirm these results.