A study on photoradiation therapy on malignant glioma using Argon laser

氩激光光放射治疗恶性胶质瘤的研究

• 批准号: 04670851
• 负责人: OHNO Kikuo
• 金额: $ 1.34万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670851/
• 关键词: Argon laser; Malignant brain tumor; Photoradiation; Rat C6 glioma model; Rat C_6 glioma model

We studied on the effects of photoradiation therapy(PRT) using the Argon laser tuned to 514.5 nm in the rat C6 glioma model and clinical patients.Our results from the study of the rat C6 glioma model with hematoporphyrin derivative(HpD) indicate that the effects of PRT on tumors include both tumor cell damage and endothelial damages of tumor vessels, and these are the main mechanisms causing tumor destruction.We have obtained clinical results from 6 patients treated with HpD and one patient most recently treated with Photofrin II.In the former group, there was no marked effect of PRT on malignant gliomas, in terms of time interval to tumor relapse and survival period. However, for the latter patient, there seems to have been a remarkable effect of PRT, indicated by MRI and CT, and histopathological findings of the specimen obtained during the second surgery. Differences of treatmant method from the 6 patients were (1)the use of Photfrin II, (2)higher power of laser, and (3)macroscopically total removal of tumor. Clinical results suggest that a new photosensitive substance, Photofrin II, may be a potent drug for treatmant of malignant glioma by means of PRT.Further investigations should be necessary to confirm these results.

我们研究了使用调至514.5 nm的氩激光进行光放射治疗（PRT）对大鼠C6胶质瘤模型和临床患者的影响。我们用血卟啉衍生物（HpD）对大鼠C6胶质瘤模型的研究结果表明，PRT对肿瘤的影响包括肿瘤细胞损伤和肿瘤血管内皮损伤，这是引起肿瘤血管内皮损伤的主要机制。 我们已经获得了 6 名接受 HpD 治疗的患者和一名最近接受 Photofrin II 治疗的患者的临床结果。在前一组中，就肿瘤复发的时间间隔和生存期而言，PRT 对恶性胶质瘤没有显着效果。然而，对于后一例患者，MRI 和 CT 以及第二次手术中获得的标本的组织病理学结果表明，PRT 似乎具有显着效果。 6例患者治疗方法的不同之处在于（1）使用Photfrin II，（2）更高功率的激光，以及（3）宏观上完全切除肿瘤。临床结果表明，一种新的光敏物质Photofrin II可能是通过PRT治疗恶性胶质瘤的有效药物。需要进一步研究来证实这些结果。

项目成果

玉置正史ら: "光化学療法による選択的抗腫瘍効果と血流障害" 第3回ニューロ・オンコロどイの会抄録集. 3. 34 (1992)

Masashi Tamaki 等人：“光化疗引起的选择性抗肿瘤作用和血流障碍”摘要来自第三届神经肿瘤学会 3. 34 (1992)。

Tamaki M, Nagano N, Aoyagi M, Ohno K, Hirakawa K :"Selective antitumor effects of and circulatory disturbance of tumor vessels by photoradiation" Proceeding of the 3rd Neuro-Oncology Meeting. 3. 34 (1992)

Tamaki M、Nagano N、Aoyagi M、Ohno K、Hirakawa K：“光辐射对肿瘤血管的选择性抗肿瘤作用和循环障碍”第三届神经肿瘤学会议论文集。