A study on photoradiation therapy on malignant glioma using Argon laser

本文研究了调谐至514.5 nm的Ar激光对大鼠C6脑胶质瘤模型和临床患者的影响。通过对含血卟啉衍生物的大鼠C6脑胶质瘤模型的研究结果表明，激光照射对肿瘤的作用包括对肿瘤细胞的损伤和对肿瘤血管内皮细胞的破坏，这是导致肿瘤破坏的主要机制。我们已经获得了6例接受HPD治疗的患者和1例最近接受PhotoFII治疗的患者的临床结果。在前一组中，从肿瘤复发时间间隔和生存期的角度来看，激光照射对恶性胶质瘤没有明显的影响。然而，对于后者，MRI和CT显示的PRT似乎有显著的效果，并且在第二次手术中获得了标本的组织病理学结果。与6例患者的治疗方法不同的是：(1)使用Photfrin II，(2)较高功率的激光，(3)肉眼全切除肿瘤。临床结果提示，一种新的光敏物质Photofrin II可能是一种通过PRT治疗恶性胶质瘤的有效药物，这些结果还需要进一步的研究来证实。

We studied on the effects of photoradiation therapy(PRT) using the Argon laser tuned to 514.5 nm in the rat C6 glioma model and clinical patients.Our results from the study of the rat C6 glioma model with hematoporphyrin derivative(HpD) indicate that the effects of PRT on tumors include both tumor cell damage and endothelial damages of tumor vessels, and these are the main mechanisms causing tumor destruction.We have obtained clinical results from 6 patients treated with HpD and one patient most recently treated with Photofrin II.In the former group, there was no marked effect of PRT on malignant gliomas, in terms of time interval to tumor relapse and survival period. However, for the latter patient, there seems to have been a remarkable effect of PRT, indicated by MRI and CT, and histopathological findings of the specimen obtained during the second surgery. Differences of treatmant method from the 6 patients were (1)the use of Photfrin II, (2)higher power of laser, and (3)macroscopically total removal of tumor. Clinical results suggest that a new photosensitive substance, Photofrin II, may be a potent drug for treatmant of malignant glioma by means of PRT.Further investigations should be necessary to confirm these results.