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Clinical appilication of video infrared fluorescein angiography to improve results of laser photocoagulation for senile disciform macular degeneration

视频红外荧光血管造影改善老年盘状黄斑变性激光光凝效果的临床应用

基本信息

批准号：
04671086
负责人：
YUZAWA Mitsuko
金额：
$ 1.34万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

1. We performed fluorescein angiography (FA) and indocyanine green video-angiography (IA) to detect choroidal neovascular membranes (CNVs) associated with senile disciform macular degeneration. we evaluated the clinical reliability of IA as a pretreatment examination for laser photocoagulation. The results were as follows :(1) IA was especially useful for eyes with extensive subretinal hemorrhage and/or exudative detachements of the retinal pigment epithelium.(2) Based on the IA findings, some choroidal neovascular membranes were obliterated with laser photocoagulation.(3) Some well-defined CNV,which were detectable with FA,showed four distinct findings on IA.The first consisted of the typical findings shown on FA.The second was slow filling with hypofluorescence in the early Phase of IA.The third was no leakage, i.e., little or no leakage from the CNV in the later phase of IA.In the fourth type, the CNV could not be demonstrated with IA.(4) We need careful evaluation on IA findings to improve the successful results when findings in FA and IA differed.2. Feeder vessel were visible in some areas of subfoveal choroidal neovascularization on indocyanine green video-angiography. We thus attempted feeder vessel treatment on eight eyes in hopes of avoiding foveal photoreceptor destruction. Additional treatments were required in seven eyes, 5 of which developed scar tissue without edema. Even though we observed decreased leakage immediately after treatment in all cases, three eyes required photocoagulation of the entire CNV due to persistent fluorescein leakage from a subfoveal CNV.When feeder vessels are detected, it is advisable to treat the feeder vessels before coagulating the subfoveal CNV.

1.我们进行荧光素血管造影（FA）和吲哚菁绿色视频血管造影（IA）来检测与老年性黄斑变性相关的脉络膜新生血管膜（CNVs）。我们评估了IA作为激光光凝术前检查的临床可靠性。结果表明：（1）IA对广泛视网膜下出血和（或）视网膜色素上皮渗出性病变的眼尤其有效。(2)根据IA的发现，一些脉络膜新生血管膜用激光光凝术消除。(3)部分边界清晰的CNV在IA上表现为四种不同的表现，第一种表现为FA上的典型表现，第二种表现为IA早期的低荧光缓慢充盈，第三种表现为无渗漏，即：第四种为IA不能显示CNV。(4)当FA和IA的结果不一致时，我们需要对IA的结果进行仔细的评估，以提高成功的结果.吲哚菁绿绿色血管造影显示部分中心凹下脉络膜新生血管可见供血血管。因此，我们尝试饲养血管治疗8只眼睛，希望避免中央凹感光细胞破坏。7只眼需要额外治疗，其中5只眼出现瘢痕组织，无水肿。尽管我们在所有病例中观察到治疗后渗漏立即减少，但由于中心凹下CNV的持续荧光素渗漏，有三只眼睛需要对整个CNV进行光凝。当检测到供血血管时，建议在切除中心凹下CNV之前治疗供血血管。