Prophyractic photocoagulation for serous drusen

浆液性玻璃疣的预防性光凝治疗

• 批准号: 10671661
• 负责人: YUZAWA Mitsuko
• 金额: $ 2.24万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671661/
• 关键词: soft drusen; choroidal neovascularization; laser photocoagulation; 加齢黄斑変性

We coagulated soft drusen which was strongly suspected of being predisposed to exudative age-related macular degeneration. During the follow-up period, soft drusen in the macular region disappeared in 14 of the 22 eyes (64%) in the study. Choroidal neovascularization was induced in one of these 14 eyes by photocoagulation. Retinal pigment epitheliumchoriocapillaris atrophy in the fovea developed in another of the 14 eyes. This eye had shown pigmentary change before this foveal atrophy occured We also followed up 98 eyes of 89 patients who met the same eligibility criteria but whose soft drusen was not coagulated. Choroidal neovascularization appeared in 11 eyes (11 %). Accumulative incidence was estimated to be 3% at one year, 39% at three years, and 64% at five years. Although the incidence of developing CNV in untreated eyes is high, the photocoagulation which we performed seems an inappropriate treatment for patients with soft drusen.

我们凝固了软玻璃膜疣，强烈怀疑它容易患渗出性年龄相关性黄斑变性。在随访期间，研究中的 22 只眼睛中有 14 只（64%）的黄斑区软玻璃疣消失。通过光凝术在这 14 只眼睛中的一只中诱导脉络膜新生血管形成。 14 只眼睛中的另一只眼睛出现中央凹视网膜色素上皮绒毛膜毛细血管萎缩。这只眼睛在中心凹萎缩发生之前就已经出现色素变化。我们还对符合相同资格标准但软玻璃膜疣未凝固的 89 名患者的 98 只眼睛进行了随访。 11只眼（11%）出现脉络膜新生血管。据估计，一年内的累积发病率为 3%，三年内为 39%，五年内为 64%。尽管未经治疗的眼睛发生 CNV 的发生率很高，但我们进行的光凝术似乎对软玻璃膜疣患者来说是不合适的治疗方法。

项目成果

湯沢美都子: "加齢黄斑変性のレーザー治療の適応"臨床眼科. 54.11. 281-284 (2000)

Mitsuko Yuzawa：“激光治疗年龄相关性黄斑变性的适应症”临床眼科 54.11（2000）。

mitsuko Yuzawa: "Exudative age-related macular degeneration"Japan Medical Association Journal. 45. 13-20 (2002)

汤泽光子：“渗出性年龄相关性黄斑变性”日本医学会杂志。

湯沢 美都子: "practical ophthalmology 眼科診療プラクティス加齢黄斑変性の診療"文光堂. 3 (1999)

Mitsuko Yuzawa：“实用眼科 - 年龄相关性黄斑变性的治疗”Bunkodo 3 (1999)。

湯沢美都子: "第104回日本眼科学会宿題報告I.黄斑疾患 滲出型加齢黄斑変性の治療"日本眼科学会雑誌. 104.12. 875-898 (2000)

Mitsuko Yuzawa：“第104届日本眼科学会作业报告I.湿性年龄相关性黄斑变性的黄斑疾病治疗”日本眼科学会杂志104.12（2000）。

Yuzawa M: "Recent treatment of exudative AMD"Asian Medical Journal. 41. 567-575 (1998)

Yuzawa M：“渗出性AMD的最新治疗”亚洲医学杂志。