Study on Expression Mechanisms of the Prolactin Receptor associated with Maternal Behavior

催乳素受体与母体行为相关的表达机制研究

• 批准号: 05807219
• 负责人: SAKAGUCHI Kesami
• 金额: $ 1.28万
• 依托单位: Mie Nursing College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05807219/
• 关键词: Prolactin Receptor; Brain; Maternal Behavior; Prolactin; Rat; プロラクチンレセプター; 肝臓; 腎臓; 性ステロイドホルモン; プロラクチンケセプター

1. Induction of maternal behavior on male and female rats.When intact, castrated male or nulliparous femal rats who had never contacted pups were exposed to rat pups, these rats initially showed relatively low levels of maternal behavior. However, maternal behavior was significantly induced in these rats during daily exposures to foster young.2. Gene expression for prolactin receptor in the brain of pup-contacted male and female rats and serum prolactin concentration.Pup contact stimulated the mRNA expression for long form prolactin receptor, but not for short form receptor in the brain of intact, castrated male and nilliparous female rats. The serum prolactin concentration in these rats was increased by pup contact, correlating with brai mRNA expression levels for long form prolactin receptor and their maternal behavior scores.

1.雄性和雌性大鼠母性行为的诱导：当从未接触过幼鼠的完整的、去势的雄性或未分娩的雌性大鼠接触幼鼠时，这些大鼠最初表现出相对较低的母性行为水平。然而，在日常暴露于养育幼鼠的过程中，这些大鼠的母性行为被显著诱导。幼虫接触雄性和雌性大鼠脑内催乳素受体基因表达和血清催乳素浓度。幼虫接触刺激正常、去势雄性和未出生雌性大鼠脑内长型催乳素受体的mRNA表达，但不刺激短型受体的mRNA表达。幼鼠接触后血清催乳素浓度升高，与长型催乳素受体BRAI基因表达水平及母体行为评分相关。

项目成果

永見,桂子: "初乳分泌量と母体の体型の相関" 母性衛生. 34. 521-526 (1993)

Nagami, Keiko：“初乳分泌与母体体形之间的相关性”《孕产妇卫生》34. 521-526 (1993)。

Sakaguchi K.: "Induction of brain prolactin receptor long form mRNA exprssion and maternal behaviorin the pup‐contacted male rats;promotion by prolactin administration and suppression by female contact" Neuroendocrinology. (in press.). (1996)

Sakaguchi K.：“幼崽接触的雄性大鼠脑催乳素受体长形式 mRNA 表达和母性行为的诱导；催乳素给药的促进和雌性接触的抑制”神经内分泌学（1996 年出版）。

Kesami Sakaguchi et al: "Induction of brain prolactin receptor lond form mRNA expression and maternal behavior in the pup-contacted male rats : promotion by prolactin administration and suppression by female contact." Neuroendocrinology. (in press).

Kesami Sakaguchi 等人：“在幼仔接触的雄性大鼠中诱导脑催乳素受体长型 mRNA 表达和母性行为：通过催乳素施用促进并通过雌性接触抑制。”

永見桂子: "初乳分泌量と母体の体型の相関" 母性衛生. 34. 521-526 (1993)

Keiko Nagami：“初乳分泌与孕妇体形之间的相关性”《孕产妇卫生》34. 521-526 (1993)。

Sakaguchi,K: "Differential regulation of prolactin receptor mRNA expression in rat liver and kidney by testosterone and oestradiol" Journal of Endocrinology. 143. 383-392 (1994)

Sakaguchi,K：“睾酮和雌二醇对大鼠肝脏和肾脏中催乳素受体 mRNA 表达的差异调节”内分泌学杂志。