Radical-Based Synthesis & Derivatization of Enantiopure Amino Acid

近年来，自由基化学经历了一次复兴，这是由于新方法的发展，使得能够在温和的反应条件下从丰富的官能团（羧酸、胺等）控制生成自由基物质。和复合类。氨基酸是手性库中最丰富的分子之一，并且是化学和生物合成的高度通用的构建块。然而，当结合时，当前的激进方法倾向于抹杀氨基酸的内在立体化学信息，从而浪费了这两个强大概念的组合所提供的巨大潜力。该研究项目的目标是开发可扩展和直接的技术，用于在自由基转化中合成和应用enatiopure氨基酸衍生物，而不会消除其固有的立体化学信息。该研究计划将提供化学和生物合成的关键构建模块，并为合成各种杂环结构提供直接途径，这些杂环结构是制药和农用化学品中的关键结构基序。此外，在拟议项目中获得的知识将用于复杂分子和天然产物合成的模块化策略的设计。

Radical chemistry has undergone a renaissance in recent years, brought about by the development of new methodologies enabling the controlled generation of radical species under mild reaction conditions from abundant functional groups (carboxylic acids, amines etc.) and compound classes. Amino acids are among the most abundant molecules in the chiral pool, and are highly versatile building blocks for chemical and biological syntheses. However, when combined, the current radical methodologies tend to obliterate the intrinsic stereochemical information of the amino acids, thus wasting the huge potential that the combination of these two powerful concepts offers. The goal of the research project is the development of scalable and straightforward technologies for the synthesis and application of enatiopure amino acid derivatives in radical transformations, without obliterating their innate stereochemical information. The research program will give access to key building blocks for chemical and biological syntheses, as well as provide direct routes for the synthesis of a wide range of heterocyclic architectures, which are key structural motifs in pharmaceutical and agrochemicals. Additionally, the knowledge gained during the proposed project will be used for the design of modular strategies for the synthesis of complex molecules and natural products.