Effet of CNS on ODC activity in rat intestine

CNS对大鼠肠道ODC活性的影响

• 批准号: 06670565
• 负责人: FUJIMOTO Kazuma
• 金额: $ 0.9万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670565/
• 关键词: ornithine; intestine; central nervous system; vagal nerve; hypothalamus; 十二指腸粘膜; 粘膜修復

The aim of the present study was to evaluate that ornithine decarboxylase (ODC) activity in the rat small intestinal mucosa is controlled, in part, by the central nervous system. In the first experiment, we demonstrated an effect of truncal vagotomy on ODC activity in the intestinal mucosa of fasted rats. The increase of ODC activity in the duodenum just before the dark period was abolished by truncal vagotomy. In the second experiment, an effect of glycoprivation of the central nervous system induced by 2-deoxy-D-glucose was shown. Infusion of 2-deoxy-D-glucose into the third cerebroventricle activated ODC in the intestinal mucosa in a dose-dependent manner. This increase was attenuated by truncal vagotomy. The results indicate that the central nervous system, in addition to local factors, is related to the increase of ODC activity in the rat intestinal mucosa.

本研究的目的是评估大鼠小肠粘膜中的鸟氨酸脱羧酶（ODC）活性部分受中枢神经系统控制。在第一个实验中，我们证明了迷走神经干切断术对禁食大鼠肠粘膜中ODC活性的影响。迷走神经干切断术可消除暗期前十二指肠ODC活性的增加。在第二个实验中，显示了由2-脱氧-D-葡萄糖诱导的中枢神经系统的糖基化效应。第三脑室注射2-脱氧-D-葡萄糖可激活肠黏膜中的ODC，并呈剂量依赖性。这种增加被迷走神经干切断术减弱。结果提示，除局部因素外，中枢神经系统也与大鼠肠粘膜ODC活性增加有关。

项目成果

M.Hirano.K.Fujimoto.et al.: "Epidermal growth factor enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate." J.Gastroenterol.30(in press). (1995)

M.Hirano.K.Fujimoto.et al.：“表皮生长因子增强了口服甲氨蝶呤受损的大鼠肠粘膜的修复。”

T.Koyama,et al: "Histamine effect on ornithine decarboxylase of rat intestine in cases of I/R compared to refeeding" Proc Soc Exp Biol Med. 209. 27-31 (1995)

T.Koyama 等人：“与重新喂养相比，缺血再灌注情况下组胺对大鼠肠道鸟氨酸脱羧酶的影响”Proc Soc Exp Biol Med。

S.Tsunada.K.Fujimoto.et al.: "Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats." Gastroenterology. 107. 1297-1304 (1994)

S.Tsunada.K.Fujimoto.et al.：“组胺受体在大鼠缺血再灌注后肠道修复中的作用。”

K.Fujimoto,et al: "Stimulatory signals from the central nervous system for ornithine decarboxylase activity in rat duodenum" Pathophysiology. 2. 25-28 (1995)

K.Fujimoto 等人：“大鼠十二指肠中鸟氨酸脱羧酶活性的中枢神经系统刺激信号”病理生理学。

T.Koyama, et al.: "Histamine effect on ornithine decarboxylase of rat intestine in cases of I/R compared to refeeding" Pro Soc Exp Biol Med. 209. 27-31 (1995)

T.Koyama 等人：“与重新喂养相比，缺血再灌注情况下组胺对大鼠肠道鸟氨酸脱羧酶的影响”Pro Soc Exp Biol Med。