Effet of CNS on ODC activity in rat intestine

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The aim of the present study was to evaluate that ornithine decarboxylase (ODC) activity in the rat small intestinal mucosa is controlled, in part, by the central nervous system. In the first experiment, we demonstrated an effect of truncal vagotomy on ODC activity in the intestinal mucosa of fasted rats. The increase of ODC activity in the duodenum just before the dark period was abolished by truncal vagotomy. In the second experiment, an effect of glycoprivation of the central nervous system induced by 2-deoxy-D-glucose was shown. Infusion of 2-deoxy-D-glucose into the third cerebroventricle activated ODC in the intestinal mucosa in a dose-dependent manner. This increase was attenuated by truncal vagotomy. The results indicate that the central nervous system, in addition to local factors, is related to the increase of ODC activity in the rat intestinal mucosa.