Maturation of central motor nervous system and development of its impairment

中枢运动神经系统的成熟及其损伤的发展

• 批准号: 06670841
• 负责人: YASUHARA Akihiro
• 金额: $ 1.15万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670841/
• 关键词: magnetic stimulation; cerebral palsy; motor evoked potential; pyramidal tract; children; somatosensory evoked potential; 磁気刺激; 運動障害; 誘発電位; 発達; 中枢運動障害

Magnetic stimulation of the motor cortex (MEP) and somatosensory evoked potential (SSEP) was used to examine the central conduction time in children with cerebral palsy. Twenty-two children with cerebral palsy (14 males and 8 females), aged between 4 to 12 years, were studied. Thirteen patients had spastic diplegia, 5 spastic quadriplegia and 4 hemiplegia, respectively. All subjects were studied in the fully awake state. Informed consent was obtained from subjects and parents. A standardized examination procedure was used with the children lying supine as relaxd as possible, with electrodes attached to the abductor pollicis brevis (APB) muscle over the thenar eminence and the abductor hallucis (AH) bilaterally. Stimulation was performed using a Nihon Koden SMN-1100 magnetic stimulator with an 8 shaped stimulator coil. MEP was recorded from APB in all patients with spastic diplegia. The mean latency of MEP,i.e.36.1 msec, from APB was longer than the latency in normal controls (20.5 msec). MEP from AH was recorded by stimulation to Cz in a patient with spastic diplegia, and 8 of the 13 patients with spastic diplegia showed responses in AH according to stimulation to the cortex of hand motor area. Patients with spastic diplegia who had responses in AH was able to walk. In one of the 5 patients with spastic quadriplegia MEP in APB was recorded, and there was no response in lower extremities. Other patients with spastic quadriplegia showed no response by magnetic stimulation. In patients with hemiplegia MEP was gained by stimulation to the healthy side of the head. SSEP did not show any specific changes in patients with CP.All of subjects did not show seizure or any other side effect. MEP studies may be useful to examine the function of patients with cerebral palsy.

用磁刺激运动皮质(MEP)和体感诱发电位(SSEP)检测脑性瘫痪患儿的中枢传导时间。脑性瘫痪患儿22例，男14例，女8例，年龄4~12岁。痉挛型双瘫13例，痉挛型四肢瘫痪5例，偏瘫4例。所有受试者都是在完全清醒的状态下进行研究。从受试者和父母那里获得知情同意。采用标准化的检查程序，儿童仰卧时尽量放松，电极连接到大鱼际隆起上方的拇短展肌(APB)和两侧的幻展肌(AH)。刺激使用Nihon Koden SMN-1100磁刺激仪和一个8型刺激器线圈。所有痉挛性双瘫患者均用APB记录MEP。APB诱发的MEP潜伏期平均为36.1毫秒，明显长于正常对照组的潜伏期(20.5毫秒)。1例痉挛双瘫患者通过刺激Cz记录到AH的MEP，13例痉挛双瘫患者中有8例根据刺激手部运动区皮质而在AH中出现反应。对AH有反应的痉挛型双瘫患者均能行走。5例痉挛性四肢瘫痪患者中有1例在APB中记录到MEP，而在双腿无反应。其他痉挛四肢瘫痪的患者在磁刺激下没有反应。偏瘫患者通过刺激健侧头部获得MEP。SSEP没有显示出任何特定的变化，所有受试者都没有出现癫痫发作或任何其他副作用。MEP检查可能有助于脑性瘫痪患者的功能检查。

项目成果

安原昭博: "Sourse derivation method(SD法)によるローランド発作波の解析" 大阪てんかん研究会雑誌. 5. 29-33 (1994)

Akihiro Yasuhara：“使用源推导法（SD 法）分析 Rolandic 癫痫波”大阪癫痫研究会杂志 5. 29-33（1994）。

Mieko Yamamura: "Source analysis of the auditory brainstem response using the dipole loca zing Method" Neurosciences. 21. 53-58 (1995)

Mieko Yamamura：“使用偶极定位方法对听觉脑干反应进行源分析”神经科学。

安原昭博: "小児における巨大SEP群とSEP無反応群" 臨床脳波. 37. 590-592 (1995)

Akihiro Yasuhara：“儿童巨型 SEP 组和 SEP 无反应组”临床脑电图 37. 590-592 (1995)。

Yue Tian, Akihiro Yasuhara, Atsushi Araki, Yohnosuke Kobayashi.: "Developmental changes of central conduction time of evoked potentials in infants and children" NO TO HATTATSU. 26. 302-307 (1994)

Yue Tian、Akihiro Yasuhara、Atsushi Araki、Yohnosuke Kobayashi.：“婴儿和儿童诱发电位中枢传导时间的发育变化”NO TO HATTATSU。

Mieko Yamamura: "Topographic study of steady of steady-state auditory evoked potentials(SSAEPs)in humans" Neurosciences. 21. 43-52 (1995)

Mieko Yamamura：“人类稳态听觉诱发电位（SSAEP）的拓扑研究”神经科学。