Establishment of Early Detection For Infantile Hearing Loss Using Distortion product otoacoustic emissions (DPOAEs)

本研究比较了畸变产物耳声发射（dpoae）和听觉脑干反应（ABR）在儿童（从新生儿重症监护病房的新生儿到青少年）听力损伤评估中的临床应用。研究对象为36例新生儿（67耳）、43例儿童（62耳）和10例成人（20耳）。dpoae和ABR均在同一天进行。使用Scout （Bio-logic Co.）记录dpoae。当ABR V波阈值为* 45 dB HL（儿童和成人均为*35 dB）时，我们将新生儿定义为听力正常。(1)用DPOAE确定DP克本底噪声（NF）。在成人中，我们获得了所有频率的dpoae，但由于噪声底高，无法获得新生儿f2=977 Hz和听力正常儿童f2= 537,684 Hz的dpoae。DPOAE记录时间比ABR短36 min；(2)我们定义为正常的dpoae，在6个f2频率，从1,416 Hz到7,959 Hz，显示dpgram噪声底限*4 dB的频率数为*4；(3) ABR与dpoae的正常阈值百分比相同，均为68.7%，但ABR与dpoae的差异百分比为6.0%。无论ABR是否正常，中耳炎伴积液患儿均未获得dpoae。我们的研究表明，DPOAIEs是一个简单的程序，可以很容易地在NICU进行，以获得可靠的结果高危新生儿。DPOAIEs获得的结果与更复杂的ABR程序获得的结果相当。DPOAE可用于检测听力障碍。

This study compares the clinical usefulness of distortion product otoacoustic emissions (DPOAEs) with the auditory brainstem response (ABR) for children (from neonates in the neonatal intensive care unit to adolescents) for the evaluation of hearing impairment.Subjects were 36 neonates (67 ears), 43 children (62 ears) and 10 adults (20 ears). Both DPOAEs and ABR were performed on the same day. DPOAEs were recorded using the Scout (Bio-logic Co.). We defined neonates as having normal hearing when the thresholds of wave V of ABR were* 45 dB HL (*35 dB in children and adults). (1) We decided DP gram - noise floor (NF) with DPOAE.In adults we obtained DPOAEs in all frequencies, but could not obtain DPOAEs at f2=977 Hz in neonates and f2=537, 684 Hz in children with normal hearing because of high noise floors. DPOAE recording time was 36 minutes shorter than that of ABR ; (2) We defined as normal DPOAEs, the number of frequencies which showed the DPgram-noise floor*4 dB was *four at six f2 frequencies, from 1, 416 Hz to 7, 959 Hz ; (3) Normal thresholds of ABR and normal DPOAEs showed the same percentages, i.e. 68.7%, but the percentage of different results between ABR and DPOAIEs was 6.0%. DPOAEs were not obtained in children with otitis media with effusion regardless normal ABR.Our study indicates that DPOAIEs represent a simple procedure, which can be easily performed in the NICU to obtain reliable results in high risk neonates. Results obtained by DPOAIEs were comparable to those obtained by the more complex procedure of ABR.DPOAE can be useful for detecting of hearing impairments.