Development of a Computer Assisted Semi-quantitative Analysis of Bone Remodeling around Bone Tumors Using Plain Radiographs.

使用X线平片对骨肿瘤周围骨重塑进行计算机辅助半定量分析的开发。

• 批准号: 06670913
• 负责人: AOKI Jun
• 金额: $ 1.34万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670913/
• 关键词: Imaging diagnosis; Image processing; Bone tumors; Biomechanics

Bone has a potency to alter its shape and internal architecture in response to mechanical stress externally loaded on it (Wolffs law) . We have developed a semi-quantitative method to assess this adaptation ability of bone on plain radiographs using a personal computer, in an attempt to utilize this phenomenon to differentiate benign bone lesions from malignant bone tumors.Seventeen normal controls, six nonossifying fibromas, four bone systs and five bone metastases in the femur were analyzed by the following method. Plain radiographs were digitized with 200 microns sampling quantization and 10 bit depth, and the digitized data were stored in an optical disc system. Within a ROI (10x10-20 cm) on the digitized images displayd on a CRT monitor screen, detection of cortical surfaces, subtraction of soft tissue density, and decision of middle points of bone density (gravity points) on all transaxial lines of the femur were automatically done through multiple calculations by a personal computer. Direction and distance of the maximum deviation of the gravity points from the line drawn from the top gravity point to the bottom one were assessed.The deviation of the gravity points was greater in the malignant tumors than in the benign bone tumors. The direction of the deviation was toward the lesions, side in the benign lesions, while it was toward the opposite side of the lesions in the malignant lesions.Our method using a concept of gravity line in the femur indicates that bone can change its construction (or mineral distribution) to support bone defects caused by benign bone lesions, and that organized bone remodeling can not occur to mechanically compensate bone defects made by malignant bone tumors. Accordingly, our semi-quantitative analysis of plain radiographs would be helpful in differentiation between benign and malignant bone tumors.

骨骼具有改变其形状和内部结构的能力，以响应外部施加的机械应力（沃尔夫定律）。为了利用这种现象来鉴别良恶性骨肿瘤，我们建立了一种半定量的方法来评价骨对X线平片的适应能力，并对17例正常对照、6例非骨化性纤维瘤、4例骨囊肿和5例骨转移瘤进行了分析。X线平片采用200微米采样量化和10位深度数字化，数字化数据存储在光盘系统中。在CRT监视器屏幕上显示的数字化图像的ROI（10 × 10 -20 cm）内，通过个人计算机的多次计算自动完成皮质表面检测、软组织密度减影和股骨所有横轴线上骨密度中点（重力点）的判定。计算骨肿瘤重力点与上、下重力点连线的最大偏差方向和距离，恶性肿瘤的重力点偏差大于良性肿瘤。在良性病变中偏向病变侧，而在恶性病变中偏向病变对侧。我们的方法利用股骨重力线的概念，表明骨可以改变其结构（或矿物质分布）来支持由良性骨病变引起的骨缺损，并且不能发生有组织的骨重建以机械地补偿由恶性骨肿瘤造成的骨缺损。因此，我们对平片的半定量分析将有助于良恶性骨肿瘤的鉴别。

项目成果

Takizawa O,Sone S,Aoki J,Imai Y,Sakai F,Karakida O,Yamasita K,Momose M,Maruyama Y,Horiguchi S,Morinaga M.: "High-resolution teleradiology system based on ISDN and small computer" NIPPON ACTA RADIOLOGICA. 55. 65-69 (1995)

Takizawa O,Sone S,Aoki J,Imai Y,Sakai F,Karakida O,Yamasita K,Momose M,Maruyama Y,Horiguchi S,Morinaga M.：“基于 ISDN 和小型计算机的高分辨率远程放射学系统” NIPPON ACTA RADIOLOGICA

滝沢正臣,他10名: "ISDNとSwall Computerによる高精細Telerodiolagy System." 日医放会誌. 55. 65-69 (1995)

Masaomi Takizawa 等 10 人：“使用 ISDN 和 Swall 计算机的高清远程放射学系统”。日本无线电学会杂志 55. 65-69 (1995)。

青木純,他2名: "局在性骨病変に伴う骨改築に及ぼす圧縮応力の影響の半定量的X線画像解析法の解析" INNERVISION. 10. 48- (1995)

Jun Aoki 等人 2：“压缩应力对与局部骨损伤相关的骨重塑的影响的半定量 X 射线图像分析”INNERVISION。

青木純,他2名: "局在性骨病変に伴う骨改築に及ぼす圧縮応力の半定量的X線画像解析法の開発" INNERVISION. 10. 48 (1995)

Jun Aoki 等人：“针对与局部骨损伤相关的骨重塑的压缩应力的半定量 X 射线图像分析方法的开发”INNERVISION。

Aoki J,Takizawa M,Karakida O: "Development of a computer assisted semi-quantitative analysis of bone remodeling around bone tumors using plain radiographs" INNERVISION. 10. 48 (1995)

Aoki J、Takizawa M、Karakida O：“使用平片放射线照片开发计算机辅助的骨肿瘤周围骨重塑半定量分析”INNERVISION。