High-resolution Imaging Analysis of Bone and Cartilage Lesions with MR Microscopy.

使用 MR 显微镜对骨和软骨病变进行高分辨率成像分析。

• 批准号: 09670916
• 负责人: AOKI Jun
• 金额: $ 2.43万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670916/
• 关键词: MRI; Bone matrix; Cartilage

The structural changes of bone observed in metabolic bone diseases and osteochondral dysplasias are too small to detect in radiologic images. Those are only microscopically observed on the surface of trabeculae of 0.15 mm thickness and in osteons of 0.15 mm in diameter. Recently, however, development of high threw rate gradient system and surface coils make it possible to detect such microscopic change on MR images.Materials and Methods : We used a small surface coil specially designed for finger imaging (GE, Fig. 1) on a 1.5-T clinical MR scanner (Signa Horizon, GE). The coil is bird-cage type with a quadrature system, impedance of 50 ohm, and in accordance with the safety standard of LEC 601-1. We performed MR microscopy of the second middle phalanges of five normal volunteers and three patients with hyperparathyroidism.Field of view (FOV) was from 2 to 4 cm, matrices were 512x512, and slice thickness was 1 mm. We used gradient echo (GRASS) sequence at the beginning, and then changed to 3D GRASS sequence for better S/N ratio. The coil was placed on a plastic table of dome type set on the examine's abdomen, so that the examine did not feel discomfort during the imaging (Fig. 2).Results : We could obtain good quality MR images, and detect the Haversian system on the MR microscopy (Fig. 3). Slightly dilatation and increase of detected number of the Haversian canal was observed in the patients with hyperparathyroidism. Image display of a narrow window width was useful to distinguish the Haversian canal from noise. In addition, detailed structure of the interphalangeal joint could be observed.Conclusion : MR microscopy may be an useful adjunct in diagnosis of metabolic bone diseases and minimal cartilage trauma.

在代谢性骨病和骨软骨发育不良中观察到的骨结构变化太小，无法在放射图像中检测到。这些仅在0.15 mm厚的骨小梁表面和0.15 mm直径的骨中显微镜下可见。然而，近年来，高抛速梯度系统和表面线圈的发展使得在MR图像上检测这种微观变化成为可能。材料和方法：我们在1.5 t临床MR扫描仪（Signa Horizon， GE）上使用专门为手指成像设计的小表面线圈（GE，图1）。该线圈为鸟笼式正交系统，阻抗为50欧姆，符合LEC 601-1安全标准。我们对5名正常志愿者和3名甲状旁腺功能亢进患者的第二中指骨进行了磁共振显微镜检查。视场（FOV）范围为2 ~ 4 cm，矩阵为512x512，切片厚度为1 mm。我们开始使用梯度回波（GRASS）序列，然后改为3D GRASS序列，以获得更好的信噪比。将线圈置于置于被检查者腹部的圆顶式塑料台上，使被检查者在成像过程中无不适（图2）。结果：我们可以获得高质量的MR图像，并在MR显微镜上检测到Haversian系统（图3）。甲状旁腺功能亢进患者哈弗森管轻度扩张，检出数目增加。窄窗宽的图像显示有助于从噪声中区分哈弗森运河。此外，还可以观察到指间关节的详细结构。结论：磁共振显微镜可作为代谢性骨病和轻度软骨损伤诊断的辅助手段。

项目成果

Aoki J,Ishijima H,Moteki T,Ishizaka H,Endo K.: "Macroscopic pathologic findings and radiographic findings of metabolic bone diseases." Kidney and Bone Metabolism. 10. 235-243 (1997)

Aoki J，Ishijima H，Moteki T，Ishizaka H，Endo K.：“代谢性骨疾病的宏观病理结果和放射学结果。”

加藤 克哉: "骨軟部組織の局在性石灰化および脂肪沈着の画像診断" 画像診断. 18. 1065-1076 (1998)

加藤胜也：“骨和软组织局部钙化和脂肪沉积的影像诊断”影像诊断。18. 1065-1076 (1998)

Aoki J.: "Magnetic resonance imaging of musculoskeletal tumores." Japanese Journal of Clinical Radiology. 43. 253-262 (1997)

Aoki J.：“肌肉骨骼肿瘤的磁共振成像。”

青木 純: "骨軟部腫瘍のMRI" 臨床放射線. 43. 253-262 (1998)

Jun Aoki：“骨和软组织肿瘤的 MRI”《临床放射学》43. 253-262 (1998)。

青木 純: "代謝性骨疾患のマクロ病理像とX線像の成り立ち" 腎と骨代謝. 10. 235-243 (1997)

Jun Aoki：“代谢性骨疾病的宏观病理图像和 X 射线图像”《Kidney and Bone Metabolism》10. 235-243 (1997)。