A study on the possible roles of brain iron associated with the pathogenesis of neuroleptic-induced tardive dyskinesia

抗精神病药物治疗的一个严重副作用是运动障碍，即迟发性运动障碍。在这项研究中，我们研究了活性氧物种在该疾病发病机制中的可能作用。获得的结果如下：1.给大鼠长期服用一种神经镇静剂氟哌啶醇。随后，用电子自旋共振(ESR)法测定脑组织中Fe^-lt；2-gt；和Fe^-lt；3-gt；的含量。结果表明，两种铁离子均无变化。但过氧化氢含量增加，脂质过氧化作用增强。一项ESR研究表明，维生素E、维生素C和依德苯酮(Avnan)具有很强的抗氧化作用。这一结果可能对下一步迟发性运动障碍的临床治疗具有重要意义。我们开发了一种检测超氧阴离子的新方法。本研究的结果和新开发的方法将为了解抗精神病药引起的传统运动障碍的详细机制提供有用的信息。

One of the serious side effects of neuroleptic therapy is a movement disorder, tardive dyskinesia. In this study, we investigated the possible roles of reactive oxygen species in the pathogenesis of the disorder. The obtained results were as follows.1. Rats were given chronic administration of a neuroleptic haloperidol. Subsequently, the levels of Fe^<2+> and Fe^<3+> in the brain were determined by means of an electron spin resonance (ESR) spectrometry. The result showed no change in both iron ions.2. However, the increase in the hydrogen peroxide and the enhancement of lipid peroxidation were observed.3. An ESR study showed a strong antioxidant effects of Vitamin E,Vitamin C,and Idebenone (Avnan). This result may be important for the next step for the clinical treatment of tardive dyskinesia.4. We developed a new method for the detection of superoxide anion.The results obtained in this study and the newly developed methods should provide a useful information for understanding the detailed mechanisms underlying the neuroleptic-induced tradive dyskinesia.