Comprehensive search of diagnostic biomarker for autism based on mass analysis of peripheral blood and birth cohort study by cord blood

基于外周血质量分析和脐带血出生队列研究的自闭症诊断生物标志物综合检索

• 批准号: 23659560
• 负责人: MORI Norio
• 金额: $ 2.33万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659560/
• 关键词: 自閉症; 質量分析; 診断マーカー; 血清; 児童・思春期精神医学

In this project, we were executing analysis to search specific protein or analyte by mass analysis using serum of individuals with autism. Then, we had a plan to identify the candidate marker molecule for early diagnosis of autism based on the birth cohort by cord blood. In proteomics analysis, we expected to execute differential display by two-dimensional electrophoresis but failed because of the equipment disorder. In metabolome analysis, we identified that free fatty acid and acyl-carnitine were increased in serum of individuals with autism as compared controls, which concluded that lipolysis was progressing in serum of individuals with autism. The birth cohort by cord blood have not yet examined within this term of grant-in-aid.

在该项目中，我们使用自闭症患者的血清进行质量分析，以寻找特定的蛋白质或分析物。然后，我们有一个计划，以确定候选标记分子的基础上，通过脐带血出生队列自闭症的早期诊断。在蛋白质组学分析中，我们期望通过双向电泳进行差异显示，但由于设备故障而失败。在代谢组学分析中，我们发现，与对照组相比，孤独症患者血清中游离脂肪酸和酰基肉毒碱增加，从而得出结论，孤独症患者血清中的脂解正在进行。本补助期内尚未检查脐带血出生队列。

项目成果

Vldlr overexpression causes hyperactivity in rats.

• DOI: 10.1186/2040-2392-3-11
• 发表时间: 2012-10-30
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Iwata K;Izumo N;Matsuzaki H;Manabe T;Ishibashi Y;Ichitani Y;Yamada K;Thanseem I;Anitha A;Vasu MM;Shimmura C;Wakuda T;Kameno Y;Takahashi T;Iwata Y;Suzuki K;Nakamura K;Mori N
• 通讯作者: Mori N

Reliability and Validity of Autism Diagnostic Interview-Revised, Japanese Version

• DOI: 10.1007/s10803-012-1606-9
• 发表时间: 2013-03-01
• 期刊: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
• 影响因子: 3.9
• 作者: Tsuchiya, Kenji J.;Matsumoto, Kaori;Takei, Nori
• 通讯作者: Takei, Nori

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