Inhibition of cytokine production and suppression of graft rejection by macrophage colony stimulating factor.

巨噬细胞集落刺激因子（M-CSF）是一种刺激单核细胞产生、突变和功能的因子。随后的研究表明，M-CSF具有多种功能，如刺激中性粒细胞和血小板的产生、抗真菌活性、杀瘤作用、诱导绒毛细胞分化、降低胆固醇、抑制动脉硬化和破骨细胞的分化和成熟。然而，M-CSF作用机制的许多点仍不清楚。我们的研究表明，在卡介苗致敏小鼠受到脂多糖（LPS）刺激时，给药M-CSF可显著抑制细胞因子的产生。

Macrophage-colony stimulating factor (M-CSF) was discovered as a factor stimulating production, muturation and function of monocytes. Subsequent investigations have revealed that M-CSF has a variety of functions such as stimulation of neutrophil and platelet production, antifungal activity, tumoricidal effect, induction of villous cell differentiation, decrease in cholesterol, suppression of arteriosclerosis and differentiation and maturation of osteoclasts. However, many points of the mechanism of M-CSF actions remain unclear. Our investigations have demonstrated that M-CSF administration markedly inhibited cytokine production in response to stimulation with lipopolysaccharide (LPS) in mice presensitized by BCG.