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Abnormalities of the blood vessels feeding the femoral head liable to osteonecrosis in spontaneously hypertensive rats

自发性高血压大鼠股骨头供血血管异常易发生骨坏死

基本信息

批准号：
06671464
负责人：
HIRANO Toru
金额：
$ 1.34万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671464/
关键词：
Spontaneously hypertensive rats Osteonecrosis of the femoral heads Blood vessels feeding the femoral heads Vascular casts Lateral epiphyseal vessels Vascular obstruction 立体的微細構造機械的圧迫 Avascular necrosis Femoral head Spontaneously hyper

项目摘要

In order to elucidate the cause of osteonecrosis of the femoral head in spontaneously hypertensive rats (SHRs), which resembles the osteonecrosis of Perthes'disease, we investigated the development of the blood vessels forming the epiphyseal nucleus of the rat femoral heads, and the abnormalities of the blood vessels feeding the femoral heads of SHRs. The vascular casts of the proximal femur were observed using both an optical and a scanning electron microscopy (SEM). In the growing rats at the age of 5 weeks, the lateral epiphyseal vessela (LEVs) budded out from the arch of the blood vessels on the femoral neck. During the period of 9-15 weeks after birth, when osteonecrosis of the femoral heads in SHRs occurred frequently, LEVs, which were the main feeding vessels, entered from the lateral of the femoral heads. Anastomosing branches of LEVs between the epiphysis and the femoral neck were scarce even in the femoral heads showing normal ossification. It seemed that the development of LEVs did not proceed normally in this period. Furthermore, remarkable segmental stenosis and the obstruction of LEVs were often recognized near the lateral of the femoral heads.These results suggested that LEVs in growing SHRs have the vascular structure that could cause an interruption of the blood supply to the femoral heads.

为了阐明自发性高血压大鼠（SHR）股骨头坏死的原因，我们观察了形成大鼠股骨头骨骺核的血管的发育，以及SHR股骨头供血血管的异常。用光学显微镜和扫描电镜观察股骨近端血管铸型。生长期大鼠在5周龄时，股骨颈血管弓处出现骺外侧血管（LEVs）。生后9-15周为自发性高血压大鼠股骨头坏死多发期，股骨头外侧有LEV进入，LEV是主要的供血血管。即使在正常骨化的股骨头中，骨骺与股骨颈之间的LEV吻合支也很少。在此期间，轻型电动车的发展似乎没有正常进行。此外，在股骨头外侧，LEV的节段性狭窄和阻塞是常见的，这些结果表明，在生长的SHR LEV的血管结构，可能会导致股骨头的血液供应中断。