Pathological study of avascular necrosis of the femoral head in spontaneously hypertensive rat

自发性高血压大鼠股骨头缺血性坏死的病理学研究

• 批准号: 63570702
• 负责人: HIRANO Toru
• 金额: $ 1.28万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570702/
• 关键词: Spontaneously hypertensive rat; Femoral head; Avascular necrosis; Perthes' disease; 大腿骨々頭; 骨頭扁平化; 骨化障害; ペルテス病類似病変

The femoral head lesions of male spontaneously hypertensive rats (SHRs), which occur naturally and resemble Perthes disease in man, were investigated radiographically and histologically. In the early phase of growth in SHRs, i.e., a period of 6 to 15 weeks after birth, the femur was shorter than that of control rats, and ossification in the epiphysis of the femoral head was considerably retarded. Osteonecrosis of the femoral head of SHRs appeared at the age of 9 weeks, and an abnormality of the cartilage in the epiphysis and metaphyseal growth plate and subsequent enchondral ossification were seen frequently. Furthermore, the cause of the vascular occlusion in osteonecrosis of the femoral head was investigated using serial sections. The lateral epiphyseal vessels, which supply the proximal femoral epiphysis, disappeared immediately before entry into the femoral heads. In fresh osteonecrosis, the pathway of the vessels between the margin of the articular cartilage and metaphyseal growth plate was replaced with granulation or scar tissue.We conclude that the vascular occlusion occurs in the layer of the epiphyseal cartilage where the lateral epiphyseal vessels penetrate, and that the abnormalities of the epiphyseal cartilage and metaphyseal growth plate might play a part in the occurrence of osteonecrosis.

对雄性自发性高血压大鼠（SHR）的股骨头病变进行了放射学和组织学研究，这种病变自然发生，类似于人类的 Perthes 病。在SHR的生长早期，即出生后6至15周期间，股骨比对照大鼠短，并且股骨头骨骺的骨化显着延迟。 SHRs的股骨头坏死在9周龄时出现，骨骺和干骺端生长板软骨异常以及随后的软骨骨化经常出现。此外，使用连续切片研究了股骨头坏死中血管闭塞的原因。供应近端股骨骨骺的外侧骨骺血管在进入股骨头之前立即消失。新鲜骨坏死时，关节软骨边缘与干骺生长板之间的血管通路被肉芽组织或疤痕组织所取代。我们推测，血管闭塞发生在侧骨骺血管所穿透的骨骺软骨层，骨骺软骨和干骺生长板的异常可能是导致骨坏死的原因之一。 发生骨坏死。

项目成果

平野徹: "高血圧自然発症ラットにおける大腿骨骨頭無腐性壊死の修復過程" 中部日本整形外科災害外科学会誌. 32. 855-857 (1989)

Toru Hirano：“自发性高血压大鼠股骨头非脓毒性坏死的修复过程”日本中央整形外科学会杂志 32. 855-857 (1989)。

平野徹: "高血圧自然発症ラットにおける大腿骨骨頭壊死-血行途絶部位とその発生機序-" 日本整形外科学会雑誌. 63. s1021 (1989)

Toru Hirano：“自发性高血压大鼠股骨头坏死 - 血液循环中断的部位及其发生机制”，日本骨科学会杂志 63. s1021 (1989)。

Katsuro Iwasaki.: Journal of Japanese Orthopaedic Assiciation.62. 1003-1010 (1988)

Katsuro Iwasaki.：日本骨科协会杂志.62。

Toru Hirano: "Osteonecrosis of the femoral head of growing,spontaneously hypertensive rats." Acta Orthopaedica Scandinavica. 59. 530-535 (1988)

Toru Hirano：“生长中的自发性高血压大鼠股骨头坏死。”

Katsuro Iwasaki: "Osteonecrosis and ossification disturbance of the femoral head of spontaneously hypertensive rats." J. Jap. Orthop. Assoc., 62, 1003-1010, 1988.

Katsuro Iwasaki：“自发性高血压大鼠股骨头坏死和骨化紊乱。”