Chaotic analysis of autonomic nervous activities during anesthesia

麻醉过程中自主神经活动的混沌分析

• 批准号: 06671515
• 负责人: KIMURA Tomomasa
• 金额: $ 1.09万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671515/
• 关键词: Autonomic nerve; Chaos; Heart rate variability; Anesthetics; Fractal; Correlation dimension; 吸入麻酔薬; イオンチャネル; 人工膜

The mechanism of action of inhalational anesthetics is unknown, but neuronal membrane alteration with chaotic purturbations caused by anesthetics is a favored hypothesis. In order to evaluate whether or not HRV have both periodic and deterministic-chaotic properties in conscious and anesthetized states, we analyzed HRV by power spectral analysis and methods of deterministic chaos.A predominant deterministic-chaotic structure of HRV with high fractal correlation dimension during conscious states altered to a more periodic structure and lower correlation dimension during general anesthesia with sevoflurane or halothane. In addition, major thoracic surgery, such as esophagectomy or pulmonary resection, diminished fractal features of HRV,suggestiong that fractal component could be an estimate of recovery state from surgical invasion.Neural control of cardiovascular system, thus, shows featrues associated with deterministic chaos by analyzing HRV changes. These results indicated the dynamic cardiovascular system that are partly characterized by non-linear natures typical for chaotic systems.

吸入麻醉药的作用机制尚不清楚，但麻醉剂引起的神经细胞膜混乱扰动是一个受欢迎的假说。为了评估HRV在清醒和麻醉状态下是否同时具有周期性和确定性-混沌特性，我们采用功率谱分析和确定性混沌方法对HRV进行了分析。在七氟醚或氟烷全身麻醉期间，HRV的主要确定性-混沌结构在清醒状态下具有较高的分维，转变为更周期性的结构和较低的关联维度。此外，大的胸部手术，如食道切除或肺切除，降低了HRV的分维特征，这表明分维分量可以作为手术后恢复状态的估计。因此，通过分析HRV的变化，心血管系统的神经控制显示出与确定性混沌相关的特征。这些结果表明，动态心血管系统具有混沌系统所特有的非线性特征。

项目成果

Komatsu, T., Singh, PK., Kimura, T., etc: "Differential effects of ketamine and midazolam on heart rate variability." Can.J.Anaesth.,. 42. 1005-1009 (1995)

Komatsu, T.、Singh, PK.、Kimura, T. 等：“氯胺酮和咪达唑仑对心率变异性的不同影响。”

Komatsu, T., Kimura, T.: "Surgical invasion and nervous system." Masui. 46. S16 (1997)

小松，T.，木村，T.：“手术侵袭和神经系统。”

木村信行、木村智政、他: "麻酔深度モニターとしての心拍変動カオス解析" 臨床モニター. 7(Supl). 47 (1996)

Nobuyuki Kimura、Tomomasa Kimura 等人：“作为麻醉深度监测器的心率变异性的混沌分析”Clinical Monitor 7（增刊）47 (1996)。

Komatsu.T,Kimura.T,et al: "Simultaneous analysis of absolute and fractional power spectra of heart rate variability is needed during anesthesia" Anesthesia and Anesthesia. 80 in press. (1995)

Komatsu.T、Kimura.T 等人：“麻醉期间需要同时分析心率变异性的绝对功率谱和分数功率谱”《麻醉与麻醉》。

Kimura, T., Komatsu, T., その他: "Autonomic imbalance of the heart during total spinal anesthesia evaluated by spectral analysis of heart rate variability." Search on Anesthesia,. 3. 10-11 (1995)

Kimura, T., Komatsu, T., et al.：“通过心率变异性频谱分析评估全脊髓麻醉期间心脏的自主神经失衡。”，Search on Anesthesia，3. 10-11 (1995)。