Effects of anesthetics on the stellate ganglion as a marker of sympathetic nervous activity

麻醉剂对星状神经节的影响作为交感神经活动的标志

• 批准号: 03670723
• 负责人: KIMURA Tomomasa
• 金额: $ 1.02万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670723/
• 关键词: STELLATE GANGLION; STELLATE GANGLION BLOCK; SYMPATHETIC NERVE; PARASYMPATHETIC NERVE; ANESTHETICS; ハロセン; サイアミラール; ケタミン; サイアミラ-ル

I have studied the effects of anesthetics on the activity of stellate ganglion utilizing nerve recording technique and the technology of spectral analysis of heart rate variability (HRV). The major results are mentioned below :(1) Marked reductions in action potentials derived from stellate ganglion cell and stellate cardiac nerve after thiamylal sodium and halothane in dose related manner.(2) Ketamine unchanged these action potentials.(3) Marked reductions in the power of HRV at all frequencies, were found after right stellate ganglion block in the patient, indicating that right stellate ganglion block decreased sympathetic and parasympathetic activities.(4) Left stellate ganglion block unchanged HRV.(5) Left stellate ganglion block increased heart rate and blood pressure, indicating relative symathetic predominance arising from total autonomic denervation.(6) Laser acupuncture applied to the skin over stellate ganglion changed skin temperature, via modulation of somatic nerve activity.(7) A relative increase in parasympathetic drive, in addition to the attenuation of sympathetic drive, was detected by spectral analysis of HRV in patients receiving total spinal anesthesia similar to the left stellate ganglion block.(8) Spectral analysis of HRV during anesthesia may provide a quantitative measure of assessing the activity of autonomic nervous system and important information of the depth of anesthesia.In conclusion, stellate ganglion may play a key role in controlling cardiovascular homeostasis.

我利用神经记录技术和心率变异性（HRV）频谱分析技术研究了麻醉剂对星状神经节活动的影响。主要结果如下：（1）硫淀粉醛和氟烷剂量相关后，星状神经节细胞和星状心脏神经的动作电位显着降低。（2）氯胺酮使这些动作电位没有变化。（3）患者右星状神经节阻滞后发现所有频率的HRV功率均显着降低，表明右星状神经节阻滞 交感神经和副交感神经活动减少。(4) 左侧星状神经节阻滞 HRV 不变。(5) 左侧星状神经节阻滞增加心率和血压，表明完全自主神经去神经支配导致交感神经相对占优势。(6) 激光针刺在星状神经节上的皮肤，通过调节躯体神经活动改变皮肤温度。(7) 副交感神经相对增加 在接受全脊髓麻醉的患者中，除了交感神经驱动力的减弱之外，通过HRV频谱分析也可以检测到与左侧星状神经节阻滞类似的驱动力。（8）麻醉过程中HRV的频谱分析可以提供评估自主神经系统活动的定量指标和麻醉深度的重要信息。综上所述，星状神经节可能在控制心血管方面发挥关键作用 体内平衡。

项目成果

Komatsu, T.et al.: "Anesthesia and monitoring of autonomic nervous activity." Byotai Seiri. 12. 631-643 (1993)

Komatsu, T.et al.：“麻醉和自主神经活动监测。”

Kato, M.et al.: "Spectral Analysis of Heart Rate Variability during Isoflurane Anesthesia." Anesthesiology. 77. 669-674 (1992)

Kato, M.et al.：“异氟烷麻醉期间心率变异性的光谱分析”。

Kimura, T.et al.: "Autonomic Imbalance of the heart during total spinal anesthesia evaluated by specgral analysis of heart Rate variabiltiy." Anesthesiology. 80. 309-312 (1994)

Kimura, T.等人：“通过心率变异性频谱分析评估全脊髓麻醉期间心脏的自主神经失衡。”

Komatsu,T.et al: "Effects of Fentanyl-Diazepam-pancuronium Anesthesia on Heart Rate Variability" J Cardiothoracic and Vascular Anesthesia. 6. 444-448 (1992)

Komatsu,T.et al：“芬太尼-地西泮-泮库溴铵麻醉对心率变异性的影响”J 心胸和血管麻醉。

木村智政 他: "心拍変動解析による自律神経活動モニタリングの臨床応用" 循環制御. 13. 433-440 (1992)

Tomomasa Kimura 等人：“使用心率变异性分析进行自主神经活动监测的临床应用”《循环控制》13. 433-440 (1992)。