权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study on the ecperimental myopia focusing on retinal function

以视网膜功能为中心的实验性近视研究

基本信息

批准号：
06671761
负责人：
FUJIKADO Takashi
金额：
$ 1.22万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671761/
关键词：
MYOPIA FORM DEPRIVATION GLUTANATE ERG RETINAL CIRCUIT CHICK 凹レンズ ON反応 OFF反応

项目摘要

(1) Intravitreal administration of kainic acid (KA), a glutamate agonist acting on AMPA/KA receptor, induce myopia with axial elongation in developing chicks, while 2-amino-phosphonobutyrate (APB), acting on metabotropic receptor, induce hyperopia with axial shortening. Both ON responses and OFF responses of ERG were reduced in eyes with KA injection, while only ON responses were specifically reduced in eyes with APB injection, suggesting that myopic change is related to the retinal circuits concerning ON and OFF responses.(2) Pattern ERG (RERG) showed reduction of amplitudes in the stimuli of the middle to high spatial frequency in eyes with KA injection, while all frequency range in eyes with APB injection, suggesting that not general reduction of retinal information processing but rather selective impairment of retinal circuits concerning the middle to high spatial frequency.(3) Chicks grown with negative lenses showed myopic change with axial elongation in relation to the power of lenses they wore. Amplitude of oscillatory potentials in eyes worn negative lenses were reduced less than that in occluded eyes, suggesting that retinal mechanism underlying axial elongation is different between lens induced and occlusion myopia.(4) Axial length of patients with corneal scar was compared between a group of early onset and that of late onset. Axial length of early onset group was significantly longer than that of late onset group, suggesting that form deprivation during childhood leads to myopia even in clinical cases.

(1)眼内注射作用于AMPA/KA受体的谷氨酸受体激动剂海人酸（KA）可诱导发育期雏鸡近视眼轴延长，而作用于代谢型受体的2-氨基膦酰基丁酸（APB）可诱导远视眼眼轴缩短。KA组ERG的ON反应和OFF反应均降低，而APB组仅ON反应特异性降低，提示近视改变与ON和OFF反应的视网膜回路有关。(2)图形ERG（Pattern ERG，RERG）显示KA组中、高空间频率刺激的振幅降低，而APB组中、高空间频率刺激的振幅均降低，提示视网膜信息处理功能的降低不是普遍性的，而是中、高空间频率视网膜回路的选择性损害。(3)负透镜生长的小鸡表现出近视眼的变化与轴向伸长有关的权力，他们穿的透镜。配戴负透镜的眼振荡电位振幅降低幅度小于遮挡眼，提示透镜近视眼和遮挡眼轴向延长的视网膜机制不同。(4)比较早发性与晚发性角膜瘢痕患者眼轴长度。早发组眼轴长度显著长于晚发组，提示儿童期形觉剥夺导致近视，即使在临床病例中。