Development of new methods to prevent the progression or recover the vision in eyes of retinitis pigmentosa

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1) We made constructs of 14 kinds of human rhodopsin mutants and injected 10 of the 14 into zebrafish embryos to establish transgenic lines for each mutation. We also performed phenotype analyses and found that the numbers of rod photoreceptors decreased in K296E, R135W, Q344X, and S334X transgenic lines. These transgenic lines are useful as a model of human retinitis pigmentosa.2) We developed a unique and novel electrode device. The device was handled easily using a vitreoretinal forceps in the vitreous cavity and was easily implanted into the optic disc with one action. The patient perceived phosphenes with electrical stimulation through each of the electrodes.