Virological velationship of human papillomavirus in the occurence of malignant

我们对17例乳头瘤患者进行了关于人乳头瘤病毒（HPV）感染的检查。17例中泪道2例，结膜15例。我们首先对标本进行了血酰木-伊红染色检查，并将其分为良性、发育不良和恶性。我们还检查了每个病例的白细胞增多症。17例，良性9例，中度发育不良1例，重度发育不良3例，原位癌2例，浸润性鳞状细胞癌2例。免疫组化染色8例阳性，原位杂交5例HPV DNA探针阳性。PCR检测4例6型HPV阳性。在一些结膜和泪道乳头状瘤的病例中，HPV在乳头状瘤的发生中有一定的作用。

We have examined 17 cases of papillomas about the infection of human papillomavirus (HPV). The content of 17 cases were 2 cases of lacrimal pathways, 15 cases of conjunctiva. Primary we have checked the specimens with hematoyxlim-eosin staining, and classified them into the benign cases, dysplastic cases, and malignat cases. We have also checlced the koilocytosis in each cases. 17 cases were, 9 benign, 1 moderate dysplastic, 3 severe dysplastic, 2 carcinoma in situ, 2 invasive squamous cell Carcinomas. According to the immunohistochemical staining, 8 cases were posine, and with the in situ hybridization 5 cases were postive against the HPV DNA probes. We have positive results in 4 cases for type6 HPV in the method of PCR.In some cases of papillomas of the conjunctiva and the lacrimal pathway, HPV has some role vole in the occurence of papillomas.