Virological velationship of human papillomavirus in the occurence of malignant

我们对17例乳头状瘤进行了人乳头状瘤病毒（HPV）感染的检测。17例内容物为泪道2例，结膜15例。我们首先对标本进行了苏木精-伊红染色，并将其分为良性病例、不典型病例和恶性病例。我们还检查了每个病例的挖空细胞。良性9例，中度不典型增生1例，重度不典型增生3例，原位癌2例，浸润性鳞癌2例。免疫组化染色阳性8例，原位杂交阳性5例。PCR检测4例6型HPV阳性，在结膜乳头状瘤和泪道乳头状瘤中，HPV与乳头状瘤的发生有一定关系。

We have examined 17 cases of papillomas about the infection of human papillomavirus (HPV). The content of 17 cases were 2 cases of lacrimal pathways, 15 cases of conjunctiva. Primary we have checked the specimens with hematoyxlim-eosin staining, and classified them into the benign cases, dysplastic cases, and malignat cases. We have also checlced the koilocytosis in each cases. 17 cases were, 9 benign, 1 moderate dysplastic, 3 severe dysplastic, 2 carcinoma in situ, 2 invasive squamous cell Carcinomas. According to the immunohistochemical staining, 8 cases were posine, and with the in situ hybridization 5 cases were postive against the HPV DNA probes. We have positive results in 4 cases for type6 HPV in the method of PCR.In some cases of papillomas of the conjunctiva and the lacrimal pathway, HPV has some role vole in the occurence of papillomas.