Virological velationship of human papillomavirus in the occurence of malignant

人乳头瘤病毒与恶性肿瘤发生的病毒学关系

• 批准号: 06671773
• 负责人: NAKAMURA Yu
• 金额: $ 0.96万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671773/
• 关键词: Ocular field; Conjunctiva; lacrimal pathway; immunohistochemical staining; Koilocytosis; in situ hybrization; porymerase chain reaction; 悪性腫瘍; パピローマウイルス

We have examined 17 cases of papillomas about the infection of human papillomavirus (HPV). The content of 17 cases were 2 cases of lacrimal pathways, 15 cases of conjunctiva. Primary we have checked the specimens with hematoyxlim-eosin staining, and classified them into the benign cases, dysplastic cases, and malignat cases. We have also checlced the koilocytosis in each cases. 17 cases were, 9 benign, 1 moderate dysplastic, 3 severe dysplastic, 2 carcinoma in situ, 2 invasive squamous cell Carcinomas. According to the immunohistochemical staining, 8 cases were posine, and with the in situ hybridization 5 cases were postive against the HPV DNA probes. We have positive results in 4 cases for type6 HPV in the method of PCR.In some cases of papillomas of the conjunctiva and the lacrimal pathway, HPV has some role vole in the occurence of papillomas.

我们对17例乳头状瘤进行了人乳头瘤病毒(HPV)感染的检查。17例中泪道2例，结膜15例。初步对标本进行苏木精-伊红染色检查，并将其分为良性、异型和恶性三类。我们还检查了每一例的凹空细胞增多症。17例，良性9例，中度异常1例，重度异常3例，原位癌2例，浸润性鳞癌2例。免疫组织化学染色阳性8例，原位杂交阳性5例。PCR法检出4例6型HPV阳性。在某些结膜和泪道乳头状瘤中，HPV在乳头状瘤的发生中有一定作用。

项目成果

Yu Nakamura et al.: "Human papilloma virus DNA detected in case of inverted squamous papilloma of the lacrimal sac" Britisch Journal of Ophthalmology. (in press).

Yu Nakamura 等人：“在泪囊内翻鳞状乳头状瘤病例中检测到人乳头状瘤病毒 DNA”《英国眼科杂志》。

Nakamura Y, et al: "Human papilloma virus DNA detected in case of inverted squamous papilloma of the lacriwd sac Br J. Ophthalmol" 94. 1995. Nakamura Y, et al (392-393)

Nakamura Y 等人：“在泪囊倒置鳞状乳头状瘤病例中检测到人乳头瘤病毒 DNA Br J. Ophamol” 94. 1995。Nakamura Y 等人 (392-393)

Nakamura Y et al: "Human Papillomavivus DNA detected in case of inverted" Squanous papilloma of the lacrimal sac Br. J. Opthalmol.94. 392-393 (1995)

Nakamura Y 等人：“在倒置”泪囊鳞状乳头状瘤 Br 的情况下检测到人乳头瘤病毒 DNA。

Nakamura Y.et al: "Human papillomavirus DNA cletected in case of inverted squamous papillomas of the lacrimal Sac." Br.J.Opthalnol. Vol.94. 392-393 (1995)

Nakamura Y.等人：“在泪囊内翻鳞状乳头状瘤的情况下检测到人乳头瘤病毒 DNA。”

Detection of human papilloma virus DNA in conjunctival and lacrimal sac papillomas: "Human pathelogy"

结膜和泪囊乳头状瘤中人乳头状瘤病毒DNA的检测：“人类病理学”