Regression effect Experimental Ocular Neovascularization with Systemic Interferon-beta

Hirohiko Miki，Motomaro Nakajima(关西医科大学)[目的]眼内新生血管导致许多眼病的视力丧失，包括角膜新生血管、新生血管性青光眼、糖尿病视网膜病变和老年性黄斑变性。目前的治疗依赖于激光光凝，涉及破坏功能性眼组织。针对新生血管的新的药理学治疗将是一个重大的进展。[方法]我们研究了人β-干扰素对兔双眼睫状长动脉结扎所致的眼前段缺血后角膜和虹膜新生血管的影响。[结果]治疗组兔眼血管造影和组织学检查均见新生血管消退，尤以虹膜新生血管消退最为明显。有角膜和虹膜新生血管记录的对照眼，未经药物治疗的所有眼均显示新生血管的进展。[结论]在角膜和虹膜新生血管的实验模型中，系统应用干扰素-β可抑制新生血管和新生血管的消退。虹膜新生血管的消退作用大于角膜。干扰素-β可能是治疗眼部新生血管疾病的有效药物。

"Regression effect of Experimental Ocular Neovascularization with Systemic Interferon-beta."Hirohiko Miki, Motomaro Nakajima(Kansai Medical University)[Purpose]Intraocular neovascularization leads to visual loss in many eye diseases, including corneal neovascularization, neovascular glaucoma, diabetic retinopathy and age-related macular degeneration. Current treatment relies on laser photocoagulation, involving the destruction of functional ocular tissues. A new phamacologic treatment directed at the newly growing vessels would represent a major advance.[Method]We studied the effect of human interferon-beta in an experimental model of corneal and iris neovascularization after ocular anterior segment ischemia produced by occlusion of both long ciliary arteries in rabbits eyes.Interferon-beta was administrated systemically to animals with angiographically documented neovascularization. Histopathological examination was also investigated with preparation after encleation on 10 and 15th day postoperatively.[Results]Rabbits eyes in the treatment group showed regression of neovascularization angiographically and histologically, especially in iris neovascularization. Control eyes with documented corneal and iris neovascularization, followed without drug treatment, showed progression of neovascularization in all eyes.[Conclusion]Systemic interferon-beta let to inhibition of neovascularization and regression of new vessels in an experimental model of corneal and iris neovascularization. It's effect of regression was more in iris neovascularization than in cornea. Interferon-beta may be effective as a medication for the treatment of the ocular neovascular diseases.