Analysis of the neural circuits related to the visually-guided orientation behavior.

与视觉引导定向行为相关的神经回路分析。

• 批准号: 06680731
• 负责人: NORITA Masao
• 金额: $ 1.47万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680731/
• 关键词: visually-guided behavior; extrastriate visual cortex; lateral suprasylvian cortex; neural circuit; corticostriatal projection; corticotectal projection; pretectum; accessory optic system; 連合線維; 皮質視蓋投射; 視蓋前域; 線条体; 視床後外側核; HRP; バイオサイチン; 免疫組織化

The present data revealed dense striate projections to PMLS and to caudal most aspect of PLLS and moderate to weak projections to AMLS/PLLS.No projection to ALLS was observed. Visually responsive along the anterior ectosylvian sulcus maintains dense interconnections ALLS/PLLS.LS is the predominate source of extrastriate visual projections to the striatum. Because striatal activity is known to modulate the activity of deep laminae output neurons in SC by way of double inhibitory GABA-ergic connections through the pars reticulata of the substantia nigra (SNr), it has been suggested that cortically-processed visual information from LS can not only influence neurons in the deep laminae of superior colliculusdirectly via corticotectal projections but also indirectly via the basal ganglia.The present results indicated that all LS regions project to various regions of the pretectal nuclei as well as all nuclei of the accessory optic system. These unclei have been known as an important visuo-m … More otor relay between the retina and pre-oculomotor structures. Furthermore, the present results on the corticotectal projections from LS confirmed those of previous studies.In the present study, the labeled axons and terminals from a single, focal injection of biocytin could be observed rostrocaudally within each bank up to rather long distance (8-10 mm) from injection site. This distance is considerably long intracortical connections, suggesting that the considerable intrinsic connectivity within LS serves not only to link subregions within a given region but across regions as well. Furthermore, following medial bank injections, a number of labeled axons and terminals were distributed in the lateral bank, while very few label could be detected in the medial bank after lateral bank injections. On the other hand, the rostralmost of ALLS-AMLS and the caudalmost of PLLS-PMLS have moderate reciprocal interconnections. Thus, the main stream of information within LS tends to be the mediolateral direction. In the present biocytin experiments, the laminar distribution of intra-areal projection exhibited a similar pattern which was independent of the rostrocaudal as well as mediolateral position of the injection site. Thus, these terminal labelings were distributed in both supra-and infragranular layrs. Furthermore, our WGA-HRP experiments indicated that ALLS,PLLS,AMLS,PMLS,and fundus all receive intra-areal afferent projections from both the supragranular and infragranular cortical layrs. Using a number of hierarchical criteria as described above, the interconnections among LS subregions seems to be no clear hierachial relationship among subregions of LS or may have feed-forward and feed-back pathways. Less

目前的数据显示密集的条纹投射到PMLS和PLL的尾部大部分方面，而对AMLS/PLLS的中等到微弱的投射，没有观察到对ALL的投射。沿着前外胚层沟的视觉反应维持着致密的相互连接。LLS是纹状体外视觉投射到纹状体的主要来源。由于已知纹状体活动通过黑质网状部(SNR)的双重抑制性GABA能联系来调节SC的深板输出神经元的活动，已有研究表明，来自LS的皮质处理的视觉信息不仅可以直接通过皮质顶盖投射影响上丘深层的神经元，也可以间接通过基底节影响深板神经元。这些人一直被认为是一个重要的视觉…更多的运动在视网膜和动眼前结构之间传递。在本研究中，在距注射部位较远(8-10 mm)的范围内，可观察到从单次局部注射生物细胞素所标记的轴突和终末的肩尾部。这一距离是相当长的皮质内连接，表明LS内相当大的内在连接不仅用于连接给定区域内的亚区，而且还用于跨区域连接。此外，内侧束注入后，外侧束内分布有大量标记的轴突和终末，而外侧束注入后，内侧束内的标记很少。而ALL-AML的吻部和PLL-PMLS的尾部具有适度的相互联系。因此，LS内的主要信息流往往是内侧方向。在目前的生物细胞素实验中，区域内投射的层状分布呈现类似的模式，与注射部位的吻尾位置和内侧位置无关。因此，这些末端标记既分布在颗粒上层，也分布在颗粒下层。此外，我们的WGA-HRP实验表明，ALL、PLL、AML、PMLS和眼底都接受颗粒上和颗粒下皮质层的区域内传入投射。使用如上所述的一些分级标准，LS亚区之间的相互联系似乎没有明确的LS亚区之间的等级关系，或者可能具有前馈和反馈通路。较少

项目成果

Norita,M.et al.: "The extra Geniculostraite visual system underlying Visually-guided Orientation hihaviorconnc:Homrand funtional implications" Newscience Res.(in press). (1995)

Norita,M.等人：“视觉引导定向 hihaviorconnc 背后的额外 Geniculostraite 视觉系统：Homrand 功能含义”Newscience Res.（正在出版）。

Norita, M., Hoshino, K., Kase, M., Meguro, R., Funaki, S., Hirano, S.and McHaffie, J.G.: "Postnatal development of corticothalamic projections from the lateral suprasylvian cortex to the lateral posterior (LP) complex in the cat : a light abd electron mic

Norita, M.、Hoshino, K.、Kase, M.、Meguro, R.、Funaki, S.、Hirano, S. 和 McHaffie, J.G.：“出生后皮质丘脑投射从外侧上外侧皮质到外侧后部的发育（

Norita M.et al.: "Extnimsic and intrimsic comnections of the cat′s latersl supeasylrian visual area" Progress in Brain Res.(印刷中).

Norita M. 等人：“猫的后侧视觉区域的外在和内在联系”《大脑研究进展》（正在出版）。

Kato I.et al.: "Pretectofugal fibers from the nueleus of the optic tract in monkeys" Brain Res.705. 109-117 (1995)

Kato I.et al.：“猴子视神经核的前覆膜纤维”Brain Res.705。

Hoshino, K., Hicks, T.P., Hirano, S.and Norita, M.: "Immunohistochemical study at the ultrastructural level of the organization of peptide, acetylcholine, and amino acid synaptic transmitters within various posterior thalamic nuclei in the cat." (Submissi

Hoshino, K.、Hicks, T.P.、Hirano, S. 和 Norita, M.：“在猫的各种后丘脑核内肽、乙酰胆碱和氨基酸突触递质组织的超微结构水平上进行免疫组织化学研究。”