The role of dopamine, reward learning and prefrontal activity in expectation-induced mood enhancement (A07)

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A07 will elucidate the neural, neurochemical, and neurocomputational pathways underlying expectation effects on negative mood and anhedonia. Using EEG in combination with a pharmacological challenge to the dopaminergic system and computational modeling of reward learning, this project will investigate how dopamine-related reward processing contributes to expectation effects on negative affect and depression-like symptoms. Results will contribute to the understanding of prefrontal and orbitofrontal activity for the generation of expectation effects in the field of mood, depressive symptoms, and pain.