The role of dopamine, reward learning and prefrontal activity in expectation-induced mood enhancement (A07)

多巴胺、奖励学习和前额叶活动在期望诱发的情绪增强中的作用 (A07)

• 批准号: 444703311
• 金额: --
• 依托单位: Arbeitsgruppe Allgemeine und Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/444703311?language=en
• 关键词: role; dopamine; reward; learning; prefrontal

A07 will elucidate the neural, neurochemical, and neurocomputational pathways underlying expectation effects on negative mood and anhedonia. Using EEG in combination with a pharmacological challenge to the dopaminergic system and computational modeling of reward learning, this project will investigate how dopamine-related reward processing contributes to expectation effects on negative affect and depression-like symptoms. Results will contribute to the understanding of prefrontal and orbitofrontal activity for the generation of expectation effects in the field of mood, depressive symptoms, and pain.

A07将阐明预期对消极情绪和快感缺乏的潜在影响的神经、神经化学和神经计算途径。使用EEG结合对多巴胺能系统的药理学挑战和奖励学习的计算建模，该项目将研究多巴胺相关的奖励处理如何有助于对负面情绪和抑郁样症状的预期效应。研究结果将有助于了解前额叶和眶额活动的预期效果在情绪，抑郁症状和疼痛领域的产生。