Disentangling pharmacologic and expectation effects in antidepressant discontinuation - a randomized, balanced open-hidden trial (A15)

项目A15将把研究抗抑郁治疗中安慰剂和反安慰剂效应所获得的知识转移到停药领域。基于对停药的功能失调预期会导致出现痛苦症状并增加停止抗抑郁药治疗后复发的风险这一观察结果，本项目将在服用SSRIs/SNRIs的患者中开展一项随机、平衡、开放-隐藏的停药试验。将改变治疗和预期因素，以系统评估其各自对停药症状发展的贡献。

Project A15 will transfer the knowledge gained in researching placebo and nocebo effects in antidepressant treatments to the field of medication discontinuation. Building on the observation that dysfunctional expectation about discontinuation contributes to the occurrence of distressing symptoms and raises the risk of relapse after stopping antidepressant treatments, this project will conduct a randomized, balanced open-hidden discontinuation trial with patients taking SSRIs/SNRIs. The factors treatment and expectation will be varied to systematically assess their respective contribution to the development of discontinuation symptoms.