A Multiscale Modelling Platform for Nanoparticle Inhalation Risk Assessment

用于纳米颗粒吸入​​风险评估的多尺度建模平台

• 批准号: DP160101953
• 负责人: Prof Jiyuan Tu
• 金额: $ 18.92万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101953
• 关键词: Multiscale; Modelling; Platform; Nanoparticle; Inhalation

This project aims to explore the health risks caused by nanoparticle inhalation and its penetration through respiratory mucus and tissue cells. Exposure to nanoparticles has the potential to cause serious and possibly fatal health effects. An understanding of nanoparticle toxicology would enable us to appropriately protect the public’s health and safety. The project plans to consider human respiratory anatomy and physiology and use advanced computer modelling and experimental techniques to evaluate the health risk of exposure to the burgeoning number of nanomaterials found in consumer products. The expected outcome of the project is a predictive tool that determines nanoparticle exposure risk and its health consequences.

该项目旨在探索纳米颗粒吸入及其通过呼吸道粘液和组织细胞的渗透引起的健康风险。暴露于纳米颗粒有可能导致严重的和可能致命的健康影响。了解纳米颗粒的毒理学将使我们能够适当地保护公众的健康和安全。该项目计划考虑人体呼吸道解剖学和生理学，并使用先进的计算机建模和实验技术来评估暴露于消费品中发现的大量纳米材料的健康风险。该项目的预期成果是一种预测工具，可以确定纳米颗粒暴露风险及其健康后果。