Intrinsically Unstructured Proteins (IUPs): NMR characterization, prediction, and application to malarial proteome

通过NMR测定具有较长DR的蛋白质结构将丰富DR数据集，并提供对蛋白质结构-功能关系和蛋白质折叠途径的更深入了解。本研究也将为结构生物学中靶点选择的关键应用领域提供有价值的信息。并不是所有当前的网络服务都是免费访问的，可用的服务可以通过使用更可靠的训练数据集或更有效的算法进一步改进，国家DR预测器的开发将帮助澳大利亚结构生物学家提高结构确定的成功率，并提供对一系列蛋白质组的更深入的了解。

Determination of protein structures with longer DR by NMR will enrich the DR dataset and provide a deeper understanding of protein structure-function relationships and protein folding pathways. The proposal will also provide valuable information in the key applied area of target selection in structural biology. Not all current web services are freely accessible and available services can be improved further by using more reliable training dataset or more effective algorithms, development of a national DR predictor will help Australian structural biologists increase the success rate of structure determination and provide greater insight into a range of proteomes.