BIOSYNTHESIS OF A FUNGAL TOXIN AND ITS ROLE IN PLANT DISEASE

真菌毒素的生物合成及其在植物病害中的作用

• 批准号: DP0558374
• 负责人: Prof Barbara Howlett
• 金额: $ 15.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558374
• 关键词: BIOSYNTHESIS; FUNGAL; TOXIN; ITS; ROLE

This project will determine how an important class of toxic molecules, epipolythiodioxopiperazines (EPTs), are made by fungi. Knowledge of the domains and actions of these genes in the biosynthetic pathway may lead to the ability to engineer secondary metabolites with altered specificity, and drugs that alleviate symptoms of secondary fungal toxicoses associated with leukemia, organ transplants and HIV AIDS. Also this project will also elucidate the role of an EPT, sirodesmin, in blackleg of canola, a disease that costs the Australian canola industry up to $50 million in losses annually. Outcomes of this project may lead to novel blackleg disease control strategies.

该项目将确定真菌如何制造一类重要的有毒分子表聚硫代二氧代哌嗪（EPT）。 这些基因在生物合成途径中的结构域和作用的知识可能会导致工程改造次级代谢产物的能力与改变的特异性，以及减轻与白血病，器官移植和HIV AIDS相关的继发性真菌中毒症状的药物。 此外，该项目还将阐明EPT sirodesmin在油菜黑胫病中的作用，油菜黑胫病是一种每年给澳大利亚油菜产业造成高达5000万美元损失的疾病。 该项目的结果可能会导致新的黑腿病控制策略。