Visible light mediated photochemical metal-free carbene transfer reactions

可见光介导的光化学无金属卡宾转移反应

• 批准号: 446530715
• 负责人: Professor Dr. Rene M. Koenigs
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/446530715?language=en
• 关键词: Visible; light; mediated; photochemical; metal

In this research project, we plan to systematically investigate photochemical, metal-free carbene transfer reactions in order to develop new and sustainable synthetic methods and to further deepen the understanding of the reactivity of carbene intermediates in organic synthesis. To achieve this goal, we will use the visible light photolysis to investigate colored donor-acceptor diazoalkanes in organic synthesis methodology. Research activities focus on the formation of free ylide intermediates via photochemically generated carbenes. These ylides are studied in sigmatropic rearrangement, cyclization, and ring expansion reactions. In the last part, we will investigate multi-carbene transfer reactions with substrates that carry several nucleophilic groups, thus opening up ways for the synthesis of oligo-cyclopropa(e)nes and fused tetrahydrofurans.

在本研究项目中，我们计划系统地研究光化学，无金属卡宾转移反应，以开发新的和可持续的合成方法，并进一步加深对有机合成中卡宾中间体反应性的理解。为了实现这一目标，我们将利用可见光光解研究有色给体-受体重氮烷在有机合成中的方法学。研究活动的重点是通过光化学生成的卡宾形成自由叶立德中间体。这些叶立德在sigmatropic重排，环化和扩环反应进行了研究。在最后一部分中，我们将研究带有多个亲核基团的底物的多卡宾转移反应，从而为低聚环内斯和稠合四氢呋喃的合成开辟途径。