Light mediated carbonylation reactions using CO 'surrogates'

使用 CO“替代物”的光介导羰基化反应

• 批准号: 2887256
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2887256
• 关键词: Light; mediated; carbonylation; reactions; using

Carbon monoxide 'surrogate' molecules can be used in carbonylation reactions to mitigate the risk of using toxic and flammable CO. Such CO releasing molecules can also be used to conveniently control CO stoichiometry for small scale reactions and where the infrastructure for handling CO is not available. This project seeks to develop novel complexes that are capable of trapping and then releasing CO when activated by UV light. To date, most CO surrogate molecules are triggered to release CO via thermal energy, however, the growing range of photocatalytic reactions mean that light activated releasing CO processes will become more important. This project aims to combine flow chemistry for light mediated carbonylation reactions and apply the system to generating carbonyl containing molecules (aldehydes, amides, esters, lactams etc.) that are relevant to the pharma and agrochemical sectors.

一氧化碳“替代”分子可用于羰基化反应，以降低使用有毒且易燃的 CO 的风险。这种释放 CO 的分子还可用于方便地控制小规模反应以及没有处理 CO 的基础设施的情况下的 CO 化学计量。该项目旨在开发能够捕获二氧化碳并在紫外线激活时释放二氧化碳的新型复合物。迄今为止，大多数 CO 替代分子都是通过热能触发释放 CO，然而，光催化反应范围的不断扩大意味着光激活释放 CO 过程将变得更加重要。该项目旨在将光介导的羰基化反应的流动化学结合起来，并将该系统应用于生成与制药和农化领域相关的含羰基分子（醛、酰胺、酯、内酰胺等）。