Light mediated carbonylation reactions using CO 'surrogates'

使用 CO“替代物”的光介导羰基化反应

• 批准号: 2887256
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2887256
• 关键词: Light; mediated; carbonylation; reactions; using

Carbon monoxide 'surrogate' molecules can be used in carbonylation reactions to mitigate the risk of using toxic and flammable CO. Such CO releasing molecules can also be used to conveniently control CO stoichiometry for small scale reactions and where the infrastructure for handling CO is not available. This project seeks to develop novel complexes that are capable of trapping and then releasing CO when activated by UV light. To date, most CO surrogate molecules are triggered to release CO via thermal energy, however, the growing range of photocatalytic reactions mean that light activated releasing CO processes will become more important. This project aims to combine flow chemistry for light mediated carbonylation reactions and apply the system to generating carbonyl containing molecules (aldehydes, amides, esters, lactams etc.) that are relevant to the pharma and agrochemical sectors.

一氧化碳“替代”分子可用于羰基化反应，以减轻使用有毒和易燃CO的风险。这种CO释放分子也可用于方便地控制CO化学计量，用于小规模反应和处理CO的基础设施不可用的地方。该项目旨在开发一种新型复合物，该复合物能够在紫外线激活时捕获并释放CO。迄今为止，大多数CO替代分子是通过热能触发释放CO的，然而，光催化反应范围的扩大意味着光激活释放CO的过程将变得更加重要。该项目旨在将流动化学与光介导的羰基化反应相结合，并应用该系统生成与制药和农化部门相关的含羰基分子（醛、酰胺、酯、内酰胺等）。