Dynamics of hepatitis B virus morphogenesis and its alterations during chronic infection (23)

乙型肝炎病毒形态发生的动态及其慢性感染过程中的变化 (23)

• 批准号: 446646872
• 金额: --
• 依托单位: Zentrum für Infektiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/446646872?language=en
• 关键词: Dynamics; hepatitis; virus; morphogenesis; its

In the serum of patients with chronic hepatitis B one does not only find complete DNA-containing virions, but also virions harbouring “empty” or RNA-containing capsids. The proportion of these forms in chronic carriers varies drastically depending on the intrahepatic viral replication activity and the treatment status. We propose that HBV particles are subject to defined ultrastructural dynamics with a series of thermodynamically driven, temporally and spatially regulated events during particle morphogenesis. This might be key to determining the fate of nucleocapsids in the host cell by deciding between either secretion as enveloped virions or recycling to the nucleus to sustain the pool of viral covalently closed circular DNA, which is the central reservoir for HBV persistence.

在慢性乙型肝炎患者的血清中，不仅可以发现完整的含dna的病毒粒子，还可以发现含有“空”或含rna的衣壳的病毒粒子。这些形式的比例在慢性携带者很大程度上取决于肝内病毒复制活性和治疗状况。我们提出HBV颗粒在颗粒形态发生过程中受到一系列热力学驱动的、时间和空间调节的超微结构动力学的影响。这可能是决定宿主细胞核衣壳命运的关键，决定是作为包膜病毒粒子分泌还是再循环到细胞核以维持病毒共价闭合的环状DNA库，这是HBV持久性的中心储存库。