Single cell approaches to define cellular programming by environmental stimuli (P02)

通过环境刺激定义细胞编程的单细胞方法（P02）

• 批准号: 448205857
• 金额: --
• 依托单位: Standort Bonn
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/448205857?language=en
• 关键词: Single; cell; approaches; define; cellular

The immune system responds to many substances present in our environment as well as lifestyle factors such as lack of exercise or Western-type diets, that can trigger inadequate immune reactions leading to chronic low-grade inflammation. Using single cell omics (SCO) technologies, we aim to understand the (inter)cellular and molecular complexity during metaflammation by developing a whole blood-based compound incubation assay to identify compounds that induce metaflammation - prototypically tested for AhR ligands-, and by translating this assay into a clinical setting to assess individual reactivities to environmental metaflammation-driving compounds.

免疫系统对我们环境中存在的许多物质以及生活方式因素（如缺乏锻炼或西式饮食）做出反应，这些因素可能引发免疫反应不足，导致慢性低度炎症。使用单细胞组学（SCO）技术，我们的目标是通过开发基于全血的化合物孵育试验来识别诱导metaflammation的化合物（原型测试AhR配体），并将该试验转化为临床环境以评估个体对环境metaflammation驱动化合物的反应性，从而了解metaflammation期间的（间）细胞和分子复杂性。