Single cell approaches to define cellular programming by environmental stimuli (P02)

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The immune system responds to many substances present in our environment as well as lifestyle factors such as lack of exercise or Western-type diets, that can trigger inadequate immune reactions leading to chronic low-grade inflammation. Using single cell omics (SCO) technologies, we aim to understand the (inter)cellular and molecular complexity during metaflammation by developing a whole blood-based compound incubation assay to identify compounds that induce metaflammation - prototypically tested for AhR ligands-, and by translating this assay into a clinical setting to assess individual reactivities to environmental metaflammation-driving compounds.