Metaflammation-induced acceleration of neurodegeneration (P15)

元炎症诱发的神经变性加速 (P15)

• 批准号: 448259731
• 金额: --
• 依托单位: Luxembourg Centre for Systems Biomedicine (LCSB)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/448259731?language=en
• 关键词: Metaflammation; induced; acceleration; neurodegeneration; P15

Midlife obesity is a well-established risk factor for Alzheimer’s disease (AD). This project will test whether Western diet-induced metaflammation activates microglia and can thereby induce cerebral inflammation that drives AD like pathology. We aim to analyse the underlying mechanisms and signal transduction pathways, in particular, the central and peripheral activation of the NLRP3 inflammasome. Our planned studies range from single cell analysis to 2-photon laser scanning in vivo analysis. To translate our findings, we will analyse the participants of the Rhineland Study. Our study will thus allow identifying patients at risk, and it will provide new therapeutic targets.

中年肥胖是阿尔茨海默病 (AD) 的一个公认的危险因素。该项目将测试西方饮食诱导的代谢炎症是否会激活小胶质细胞，从而诱发脑部炎症，从而导致 AD 样病理学。我们的目的是分析潜在的机制和信号转导途径，特别是 NLRP3 炎症小体的中枢和外周激活。我们计划的研究范围从单细胞分析到 2 光子激光扫描体内分析。为了转化我们的发现，我们将分析莱茵兰研究的参与者。因此，我们的研究将能够识别处于危险中的患者，并将提供新的治疗靶点。