THE ROLE OF MEDIUM SPINY NEURONS IN SLEEP DEPRIVATION-INDUCED COGNITIVE RIGIDITY.

中型棘神经元在睡眠剥夺引起的认知僵化中的作用。

基本信息

  • 批准号:
    10656057
  • 负责人:
  • 金额:
    $ 22.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

ABSTRACT This project is focused on understanding the mechanisms behind performance deficits that occur with insufficient sleep. In particular, studies in humans have identified cognitive rigidity (compromised situational adaptability in decision making) as a consequence of sleep deprivation (SD). Cognitive rigidity is influenced by a striatopallidal brain circuit that is conserved in subhuman primates and rodents and involves a cell type that expresses dopamine-type 2 (DrD2) and adenosine-type 2a (A2a) receptors. In the current studies, we will employ mouse electrophysiology recordings and real-time striatal event imaging, in addition to a rat cognitive flexibility task that is susceptible to SD. We will apply these techniques to transgenic mouse and rat models in order to interrogate the role of the DrD2/A2a striatopallidal brain circuit in mediating the effects of SD at the biochemical, receptor, regional (brain structure and electrophysiology) levels in addition to probing complex whole organism behavior. In Aim 1, we will determine the extent to which DrD2 cell membrane localization and intracellular cyclic adenosine monophosphate concentration ([cAMP]i) in striatal medium spiny neurons vary as a function of spontaneous and SD-induced sleep/wake cycles. This experiment will address our dynamic interplay hypothesis that striatal DrD2 receptor availability and the inversely-related [cAMP]i function as cellular mediators of sleep pressure in the striatum. In Aim 2, we will examine whether the activity of striatal DrD2/A2a cells is necessary and sufficient to confer the negative impacts of SD on cognitive flexibility. We predict that cell-type specific chemogenetic activation or inactivation of these neurons will mimic or rescue, respectively, the behavioral consequences of SD in a touchscreen operant reversal task. The anticipated results of this project will confirm the mechanistic role of the striatopallidal medium spiny neuron population in the performance decrements that stem from sleep loss. Here, our focus is on dopaminergic signaling, but our long-term objective is to elucidate how signaling mechanisms in the striatum and connected brain areas converge to regulate the cognitive processes that are compromised by SD. Overall, this work will set the stage for future inquiries by confirming cell type-specific SD mitigation targets in striatal circuitry. It will also inform the public and scientific constituencies of potential mechanistic and compensatory approaches to reversing/preventing the deleterious effects of sleep loss.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Christopher John Davis其他文献

Christopher John Davis的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Christopher John Davis', 18)}}的其他基金

"Uncoupling sleep deprivation-associated stressors from sleep loss in rodents"
“将啮齿动物睡眠不足与睡眠不足相关的压力源分开”
  • 批准号:
    8822760
  • 财政年份:
    2014
  • 资助金额:
    $ 22.95万
  • 项目类别:

相似海外基金

Factors and effect of visual inattention on fall accidents
视觉注意力不集中对坠落事故的影响因素及影响
  • 批准号:
    23K19000
  • 财政年份:
    2023
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
SBIR Phase I: Comprehensive, Human-Centered, Safety System Using Physiological and Behavioral Sensing to Predict and Prevent Workplace Accidents
SBIR 第一阶段:利用生理和行为感知来预测和预防工作场所事故的综合性、以人为本的安全系统
  • 批准号:
    2321538
  • 财政年份:
    2023
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Standard Grant
Preventing Accidents in School lunch for Food Allergies: Consideration of Strategies and Development of Support Applications.
预防学校午餐中的食物过敏事故:考虑策略和开发支持应用程序。
  • 批准号:
    23K01977
  • 财政年份:
    2023
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Political Geographies of Human Accidents and Trauma Care in Mumbai's Commuter Railways
孟买通勤铁路中人类事故和创伤护理的政治地理
  • 批准号:
    ES/X006239/1
  • 财政年份:
    2022
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Fellowship
Multiscale, Multi-fidelity and Multiphysics Bayesian Neural Network (BNN) Machine Learning (ML) Surrogate Models for Modelling Design Based Accidents
用于基于事故建模设计的多尺度、多保真度和多物理场贝叶斯神经网络 (BNN) 机器学习 (ML) 替代模型
  • 批准号:
    2764855
  • 财政年份:
    2022
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Studentship
OTIMO - Applying telematics to the learner driver market through innovations in AI and behavioural intervention, to improve driving and reduce accidents.
OTIMO - 通过人工智能和行为干预创新,将远程信息处理应用于学习驾驶员市场,以改善驾驶并减少事故。
  • 批准号:
    10035763
  • 财政年份:
    2022
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Collaborative R&D
Comprehensive safety strategy to achieve reducing accidents of central venous access port catheter rapture
综合安全策略,实现减少中心静脉通路导管断裂事故
  • 批准号:
    22K17330
  • 财政年份:
    2022
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Practical application of exposure dose evaluation method by DNA damage analysis for radiation exposure accidents
DNA损伤分析照射剂量评估方法在辐射事故中的实际应用
  • 批准号:
    21H01861
  • 财政年份:
    2021
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Computational Scientific Study on Mechanism of Multiphase Thermal-Hydraulic Phenomena Related to IVR in Core Disruptive Accidents
堆芯破坏性事故中与IVR相关的多相热工水力现象机理的计算科学研究
  • 批准号:
    21K04944
  • 财政年份:
    2021
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Crutch Walk Training with AR Presentation of Near Miss Accidents by Disturbances in Living Space
拐杖行走训练与 AR 展示生活空间干扰造成的未遂事故
  • 批准号:
    21K12816
  • 财政年份:
    2021
  • 资助金额:
    $ 22.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了