THE ENCODING OF SENSORY INFORMATION AND EXPECTATIONS IN THE CEREBRAL PROCESSING OF PAIN

大脑处理疼痛时感觉信息和期望的编码

基本信息

项目摘要

Pain serves to protect the body. To this end, the brain translates sensory information about threat into pain. This translation is, however, not linear but substantially influenced by an individual’s expectations. Such expectancy effects represent an essential part of every pain treatment. Moreover, expectations can significantly contribute to the development and long-term outcomes of chronic pain. However, how the brain encodes sensory information and expectations in the processing of pain is not fully understood yet. To address this question, we will perform a series of electroencephalography (EEG) experiments. We will build upon recent predictive coding concepts of brain function and pain processing to systematically assess the role of brain activity in the signaling of sensory information, expectations, prediction errors and pain perception. In four experiments, experimental pain stimuli will be applied to 50 healthy human participants and noxious stimulus intensity and the participants’ expectations of pain intensity will be manipulated independently. Analyses will apply most recent model-based functional imaging approaches to state-of-the-art analyses of EEG data. Harnessing the high temporal resolution of EEG, we will quantify the relationship between brain activity at different latencies and frequencies and the encoding of stimulus intensity, expectations (predictions), prediction errors and combinations of these elements. The synopsis of the different experiments will show how these relationships generalize to different manipulations of sensory information and expectations. As the interaction of sensory information and expectations is at the heart of the pain experience, the project promises fundamental insights into the brain mechanisms of pain. Moreover, as the interaction of sensory information and expectations is often altered in chronic pain, the project promises to further the understanding of the brain mechanisms of chronic pain. Finally, as expectations significantly shape treatment effects in pain therapy, the project might help to understand and optimize pain treatment.
疼痛是为了保护身体。为此,大脑将有关威胁的感官信息转化为疼痛。然而,这种转换不是线性的,而是受到个人期望的重大影响。这种预期效应是每一种疼痛治疗的重要组成部分。此外,期望可以显着促进慢性疼痛的发展和长期结果。然而,大脑如何在疼痛处理中编码感官信息和期望尚未完全了解。为了解决这个问题,我们将进行一系列的脑电图(EEG)实验。我们将建立在大脑功能和疼痛处理的最新预测编码概念的基础上,系统地评估大脑活动在感觉信息,期望,预测错误和疼痛感知信号中的作用。在四个实验中,实验性疼痛刺激将被施加到50名健康的人类参与者和伤害性刺激强度和参与者的疼痛强度的预期将被独立操纵。分析将应用最新的基于模型的功能成像方法,以最先进的EEG数据分析。利用EEG的高时间分辨率,我们将量化不同频率和频率下的大脑活动与刺激强度、预期(预测)、预测误差和这些元素组合的编码之间的关系。不同实验的概要将显示这些关系如何推广到对感官信息和期望的不同操作。由于感觉信息和期望的相互作用是疼痛体验的核心,该项目有望对疼痛的大脑机制产生根本性的见解。此外,由于感觉信息和期望的相互作用在慢性疼痛中经常改变,该项目有望进一步了解慢性疼痛的大脑机制。最后,由于预期显著影响疼痛治疗的治疗效果,该项目可能有助于理解和优化疼痛治疗。

项目成果

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Professor Dr. Markus Ploner其他文献

Professor Dr. Markus Ploner的其他文献

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{{ truncateString('Professor Dr. Markus Ploner', 18)}}的其他基金

Neurophysiological mediators of perceptual, motor and autonomic components of pain
疼痛的知觉、运动和自主成分的神经生理介质
  • 批准号:
    317413324
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Neurophysiological mechanisms of pain
疼痛的神经生理机制
  • 批准号:
    230651263
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Heisenberg Professorships
Brain network correlates of tonic and chronic pain
强直性疼痛和慢性疼痛的大脑网络相关性
  • 批准号:
    230335848
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Neuronale Oszillationen und Synchronisation in der menschlichen Schmerzverarbeitung
人类疼痛处理中的神经振荡和同步
  • 批准号:
    57587620
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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