Neuronale Oszillationen und Synchronisation in der menschlichen Schmerzverarbeitung

复杂的疼痛体验是由一个扩展的大脑区域网络提供的。最近的证据表明，疼痛刺激可以调节部分脑疼痛网络的神经元振荡和同步。然而，一个全面的空间和时间表征的疼痛相关的神经元振荡和同步尚未进行。此外，这些疼痛相关现象的功能意义在很大程度上仍然未知。因此，我们将使用脑电图来研究人类大脑中疼痛引起的振荡和同步性。在一系列的四个实验中，我们将应用先进的分析技术来确定不同频段疼痛诱导的神经元振荡的空间和时间。此外，我们将探索局部振荡之间的同步性，作为大脑区域之间疼痛相关通信的衡量标准。疼痛诱发的振荡和同步将与自发的神经元振荡和众所周知的疼痛诱发反应有关。不同的知觉和运动范式将应用于研究疼痛诱发振荡和同步对疼痛感知和行为反应的功能意义。因此，该项目旨在提供人类大脑中与疼痛相关的复杂体验的神经生理现象的空间、时间和功能概述。

The complex experience of pain is subserved by an extended network of brain areas. Recent evidence shows that painful stimuli modulate neuronal oscillations and synchrony in parts of the cerebral pain network. However, a comprehensive spatial and temporal characterization of pain-related neuronal oscillations and synchrony has not yet been carried out. Moreover, the functional significance of these pain-related phenomena has remained largely unknown. We will therefore use electroencephalography to investigate pain-induced oscillations and synchrony in the human brain. In a series of four experiments, we will apply advanced analysis techniques to spatially and temporally determine pain-induced neuronal oscillations in different frequency bands. Furthermore, we will explore synchrony between local oscillations as a measure of pain-related communication between brain areas. Pain-induced oscillations and synchrony will be related to spontaneous neuronal oscillations and to the well-known pain-evoked responses. Different perceptual and motor paradigms will be applied to investigate the functional significance of pain-induced oscillations and synchrony for the perception of and behavioral reactions to pain. The project is thus intended to provide a spatial, temporal and functional synopsis of neurophysiological phenomena in the human brain related to the complex experience of pain.