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Development of functional composite membrane and its application to the materials for dental regeneration

功能性复合膜的研制及其在牙齿再生材料中的应用

基本信息

批准号：
14207086
负责人：
BAN Seiji
金额：
$ 31.53万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

Needle-like apatites were successfully formed on titanium plate, bar, and mesh by a hydrothermal-electrochemical method in an electrolyte containing calcium and phosphate ions. The deposited needle-like apatites were homogeneously and vertically oriented to the substrate surface. Morphology and crystallinity of the deposited apatite were easily regulated by the electrolytic conditions such as composition and temperature of electrolyte, current density, and substrate.The electrochemical deposition process of apatite was real-time monitored using an electrochemical quartz crystal microbalance. It seemed that the electrochemical apatite deposition may be controlled by ion diffusion at the boundary between the electrode and the electrolyte, and the electric current loading may reduce the activation energy for it.We applied to produce a novel fabrication method of a composite membrane consisting of oriented needle-like apatite and biodegradable polymer for tissue regeneration in dentistry a … More nd medicine. The properties of the composite membrane can be easily controlled ; e.g. the degradation rate of this membrane can be regulated by the thickness of the copolymer, which can be controlled by concentration and dropped volume. It was confirmed that this composite membrane has a good biocompatibility with soft tissue and hard tissue. Furthermore, BMP was applied on this composite membrane and produced the biologically active membrane.Needle-like apatites were coated on titanium mesh using hydrothermal-electrochemical method, and its biocompatibility was investigated through the behavior of mouse MC3T3-E1 osteoblast-like cells. The osteoblast-like cells attached and extended on the deposited apatite and no detrimental effects were observed on the development of the cell. After measuring alkaline phosphatase activity as well as collagen and osteocalcin of the extracellular matrix, the electrochemically apatite-coated titanium mesh indicated higher values than the titanium mesh without coating. These results suggest that the deposited apatite on titanium mesh has excellent biocompatibility. Less

在含钙和磷酸根离子的电解液中，采用水热-电化学方法在钛板、钛棒和钛网上成功地制备了针状磷灰石。沉积的针状磷灰石是均匀的，并垂直于基板表面。沉积磷灰石的形貌和结晶度容易通过电解液的组成、温度、电流密度和基体等电解条件进行调节，利用电化学石英晶体微天平对磷灰石的电化学沉积过程进行实时监测。本研究采用电化学方法制备了定向针状磷灰石和生物可降解聚合物的复合膜，并将其应用于口腔组织再生领域。 ...更多信息和医学。复合膜的性质可以容易地控制;例如，该膜的降解速率可以通过共聚物的厚度来调节，共聚物的厚度可以通过浓度和滴加体积来控制。证实了该复合膜与软组织和硬组织具有良好的生物相容性。采用水热-电化学方法在钛网表面包覆针状磷灰石，通过小鼠成骨样细胞MC 3 T3-E1的行为研究其生物相容性。成骨样细胞在沉积的磷灰石上贴壁生长，对细胞的生长发育无不良影响。在测量碱性磷酸酶活性以及细胞外基质的胶原蛋白和骨钙素后，电化学磷灰石涂层钛网显示出比无涂层钛网更高的值。这些结果表明，钛网表面沉积的磷灰石具有良好的生物相容性。少