Electrochemical synthesis of biocompatible calcium phosphate film and its application on dental implant

生物相容性磷酸钙薄膜的电化学合成及其在牙种植体中的应用

• 批准号: 05671645
• 负责人: BAN Seiji
• 金额: $ 1.34万
• 依托单位: Aichi-Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671645/
• 关键词: hydroxyapatite; carbonate apatite; electrochemical synsthesis; dental implant; coating; calcium phosphate; 非晶質

The present thesis deals with the surface modification by the electrochemical deposition of bioactive layr on the composite designed for biological application. In Heisei 5, the electrochemical deposition of calcium phosphate on titanium in simulated body fluid was studied. The suitable condition for the electrochemical deposition of the calcium phosphate, which is apatite having low crystallinity and containing no other crystal phase, was given. In Heisei 6, the formation of needle-like apatite crystal by electrochemical depositionwas focused in the research. The suitable condition for the formation of needle-like apatite coating was derived from the experimental results in Heisei 5. The effect of the needle-like apatite coating formed by the electrochemical method on the biological activities of the HA-G-Ti composite was confirmed. The present study demonstrated that the formation of needle-like apatite on the composite and titanium can promote the new bone formation in the early stages of implantation.

本论文采用电化学方法在生物复合材料表面沉积生物活性涂层进行表面改性。在Heisei 5中，研究了在模拟体液中，磷酸钙在钛表面的电化学沉积。给出了电化学沉积低结晶度、不含其他晶相的磷灰石的适宜条件。在平成6号中，重点研究了电化学沉积形成针状磷灰石晶体的过程。由平成5号的实验结果得出了形成针状磷灰石涂层的适宜条件。证实了电化学方法形成的针状磷灰石涂层对HA-G-Ti复合材料生物活性的影响。本研究表明，在种植早期，复合材料和钛表面形成的针状磷灰石可以促进新骨的形成。

项目成果

Seiji Ban: "Calcium phosphate precipitation on the surface of HA-G-Ti composite under physiological conditions" J.Biomed.Mat.Res.28. 65-71 (1994)

Seiji Ban：“生理条件下HA-G-Ti复合材料表面磷酸钙沉淀”J.Biomed.Mat.Res.28。

Seiji Ban: "Effect of temperature on electrochemical deposition of calcium phosphate coatings in a simulated body fluid" Biomateriais. 印刷中. (1995)

Seiji Ban：“温度对模拟体液中磷酸钙涂层电化学沉积的影响”Biomateriais（1995 年）。

Tomoji Ishikawa: "Effect of hydroxyapatite containing glass coating on the bonding between bone and titanium implant" Clinical Materials. 14. 277-285 (1993)

Tomoji Ishikawa：“含羟基磷灰石玻璃涂层对骨和钛植入物之间粘合的影响”临床材料。

T.Ishikawa, H.Itoh, S.Maruno, H.Iwata, and S.Ban: "Effect of hydroxyapatite containing glass coating on the bonding between bone and titanium implant" Clinical Materials. 14. 277-285 (1993)

T.Ishikawa、H.Itoh、S.Maruno、H.Iwata 和 S.Ban：“含羟基磷灰石玻璃涂层对骨与钛植入物之间粘合的影响”临床材料。

Seiji Ban: "Deposition of Calcium Phosphate on Titanium by Electrochemical Process in Simulated Body Fluid." Jpn.J.Appl.Phys.32(10B). L1577-1580 (1993)

Seiji Ban：“在模拟体液中通过电化学过程在钛上沉积磷酸钙。”