Clinical research for relationship between periodontal disease and systemic disease

牙周病与全身性疾病关系的临床研究

• 批准号: 15209071
• 负责人: KURIHRA Hidemi
• 金额: $ 33.86万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15209071/
• 关键词: periodontitis; daibetes; systemic disease; atherosclerosis; epidemiology; 歯周炎; インスリン抵抗性; 循環器疾患; 口腔ケア; 全身疾患

The purpose of this research is to identify the relationship between periodontitis and systemic disease such as diabetes, atherosclerosis, et al. in Japanese. We collaborated with 13 university in Japan and progressed this research. As results, we got some new views as follows.1. Periodontitis is associated with diabetes in Japanese subjects.2. Periodontitis is also associated with atherosclerosis and other systemic disease in Japanese.3. Periodontal treatment improve the diabetic condition to healthy one.4. Examination of the effects of surgery or non-surgery periodontal therapy in diabetic patients.5. Examination of relationship between paeriodontits and high blood pressure.6. Periodontal bacteria affect cardiovascular disease.We got many new views on periodontal medicine in Japanese. Periodontitis is tightly associated with systemic disease such as diabetes, atherosclerosis, low weight birth, and others. It was clear that periodontal treatment improve systemic condition. After treatment of periodontitis, diabetic index was improved.In the future, we have to continue this research to identify the relationship between periodontitis and sysytemic disease. And we have to develop new therapy of periodontitis on the basis of EBM(evidence based medicine).

本研究的目的是确定牙周炎与全身性疾病如糖尿病、动脉粥样硬化等的关系。我们与日本的13所大学合作，进行了这项研究。结果表明：1.牙周炎与日本受试者的糖尿病相关。在日本，牙周炎还与动脉粥样硬化和其他系统性疾病有关.糖尿病患者经周期性治疗后，病情明显好转，恢复到健康状态.糖尿病患者牙周手术治疗与非手术治疗的效果比较.检查副牙本质与高血压的关系.牙周病细菌与心血管疾病的关系。牙周炎与全身性疾病如糖尿病、动脉粥样硬化、低体重儿等密切相关。很明显，牙周治疗改善全身状况。牙周炎治疗后，糖尿病指数有所改善，但牙周炎与系统性疾病的关系仍有待进一步研究。因此，我们必须在循证医学的基础上开发新的牙周炎治疗方法。

项目成果

A tumor necrosis factor-α antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice

• 发表时间: 2004
• 作者: 鈴木 賀文

T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis

• DOI: 10.1111/j.0902-0055.2004.00134.x
• 发表时间: 2004-06-01
• 期刊: ORAL MICROBIOLOGY AND IMMUNOLOGY
• 作者: Yamazaki, K;Ohsawa, Y;Seymour, GJ
• 通讯作者: Seymour, GJ

Antimicrobial periodontal treatment decreases serum c-reactive protein, TNF-alpha, but not adiponectin levels in patients with chronic periodontitis

抗菌牙周治疗可降低慢性牙周炎患者的血清 C 反应蛋白、TNF-α 水平，但不会降低脂联素水平

• 发表时间: 2003
• 期刊: J Periodontol 74・8
• 作者: 谷川恵一;高橋則子;Inoue M;Fusanori Nishimura
• 通讯作者: Fusanori Nishimura

Oral bacteria in the occluded arteries of patients with Buerger disease

• DOI: 10.1016/j.jvs.2005.03.016
• 发表时间: 2005-07-01
• 期刊: JOURNAL OF VASCULAR SURGERY
• 影响因子: 4.3
• 作者: Iwai, T;Inoue, Y;Ishikawa, I
• 通讯作者: Ishikawa, I

Periodontal infection and dyslipidemia in type2 diabetics Association with increased HMG-CoA reductase expression

2 型糖尿病患者牙周感染和血脂异常与 HMG-CoA 还原酶表达增加的关系

• 发表时间: 2006
• 期刊: Hormone and Metabolic Research (In press)
• 作者: Motoko Okitsu;Hidekazu Takahashi;Takatomo Yoshioka;Naohiko Iwasaki;Hideaki Suda;Li M-H et al.;Fusanori Nishimura
• 通讯作者: Fusanori Nishimura