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Construction of Infared-Excitation Nano-meter Scale Spectroscopic Surface Analyzer and Its Application to Polymer-Water Interfaces

红外激发纳米级光谱表面分析仪的构建及其在聚合物-水界面中的应用

基本信息

批准号：
16205015
负责人：
KITANO Hiromi
金额：
$ 22.63万
依托单位：
University of Toyama
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

The structure and hydrogen bonding of water in the vicinity of zwitterionic polymers such as PolyCMB (CMB, carboxybetaine monomer) and a random copolymer of CMB and n-butyl methacrylate, Poly(CMB-r-BMA), were analyzed in their aqueous solutions and thin film using vibrational spectroscopy. The number of hydrogen bonding collapsed by the presence of one monomer residue (N_<corr> value) of water-soluble zwitterionic polymers were much smaller than those for ordinary polyelectrolytes and close to those for nonionic water-soluble polymers. Furthermore, the O-H stretching band of vibrational spectra for the water incorporated in the film of zwitterionic copolymer with a large BMA content was similar to that for free water, which is in contrast with the drastic change in the O-H stretching band of water incorporated in polymer films such as poly(methyl methacrylate) (PMMA) and poly(n-butyl methacrylate) (PBMA). The observation with an atomic force microscope (AFM) confirmed the responsiveness of zwitterionic copolymer films to the sorption and desorption of water from the polymer films. The adhesion of platelets to zwitterionic copolymer films (Poly(CMB-r-BMA), for example) was much less than that to PMMA and PBMA. With an increase in the content of CMB residue, the number of human platelets adhered to the Poly(CMB-r-BMA) film drastically decreased and then gradually increased, probably due to the increase in the roughness of the film surface. These results suggest that the monomer residues with a zwitterionic structure do not significantly disturb the hydrogen bonding between water molecules in both aqueous solution and thin film systems, resulting in the excellent blood-compatibility of the zwitterionic polymers.

用振动光谱法分析了两性离子聚合物如聚CMB（CMB，羧基甜菜碱单体）和CMB与甲基丙烯酸正丁酯的无规共聚物Poly（CMB-r-BMA）在其水溶液和薄膜中的结构和附近水的氢键。水溶性两性离子聚合物中因一个单体残基的存在而瓦解的氢键数（N<corr>值）远小于普通聚电解质，而与非离子型水溶性聚合物接近。此外，BMA含量较大的两性离子共聚物膜中水的O-H伸缩振动谱带与自由水的O-H伸缩振动谱带相似，这与聚甲基丙烯酸甲酯（PMMA）和聚甲基丙烯酸正丁酯（PBMA）等聚合物膜中水的O-H伸缩振动谱带的剧烈变化形成对比.用原子力显微镜（AFM）的观察证实了两性离子共聚物膜对水从聚合物膜的吸附和解吸的响应性。血小板对两性离子共聚物膜（如Poly（CMB-r-BMA））的粘附力远小于对PMMA和PBMA的粘附力。随着CMB残留量的增加，粘附在Poly（CMB-r-BMA）膜上的人血小板数量急剧减少，然后逐渐增加，这可能是由于膜表面粗糙度的增加。这些结果表明，具有两性离子结构的单体残基不会显著干扰水溶液和薄膜系统中的水分子之间的氢键，从而导致两性离子聚合物的优异的血液相容性。