In vitro chemosensitivity test to predict chemosensicivity for paclitaxel, using human gastric carcinoma tissues.

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In order to evaluate the clinical, usefulness of in vitro chemosensitivity assays for adjuvant chemotherapy for locally advanced gastric cancer, this research group members regularly convene to have discussion to launch up the multi-institutional randomized clinical trial. As one of results, Japan Clinical Cancer Research Organization (JCCRO) involving 36 surgical institutions that scatter nation-wide has agreed to start a new phase II clinical study in which each of patients undergoes postoperative adjuvant chemotherapy with TS-1, oral fluorouridine, would provide any survival advantage for patients with in vitro sensitivity to 5-FU locally advanced gastric cancer. In vitro chemosensitivity is assessed by a CDDST method. The primary endpoint is relapse free aurvival at 3 years after surgery, and the secondary endpoints are overall survival (OS) and to identify whether the patients with in vitro higher response to 5-FU would have better OS than those with in vitro lower response to 5-FU. Patient accrual started on 21st July, 2005, Patients' registry will finish until June, 2009.