Genome-wide microsatellite mapping of multi-factorial ocular diseases.
多因素眼部疾病的全基因组微卫星图谱。
基本信息
- 批准号:16209052
- 负责人:
- 金额:$ 30.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2006
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to identify susceptibility genes associated with ocular diseases and hypertension, we have performed association study, using 25000 microsatellites(MS) and pooled DNA. The progresses of each disease is as follows.High myopia : 534 samples were collected. After the first, second and third screen, 156 positive markers were passed. As a result of indivisual typing, 26 positive markers were obtained. SNP typings were performing in the surrounding each candidate regionBehcet disease : 427 samples were collected. The first, second and third MS screenings and individual genotyping were finished, and 11 positive markers were obtained. SNP typing are performing in the surrounding each candidate regions.Lattice degeneration : 397 samples were collected. In the first screening, we found significant association for 2851 markers.Hypertension : 508 samples were collected. MS screenings were finished and 135 positive markers were obtained. Individual typing then were performed, and 55 markers were passed. SNP genotyping are performing now.Glaucoma : 192 samples were collected. The first screen using 138 samples was performed and 13.8% positive markers were obtained. The second screen is performing now. Simultaneously, SNP typings using GeneChip are performing.
为了鉴定与眼部疾病和高血压相关的易感基因,我们使用25000个微卫星(MS)和混合DNA进行了关联研究。每种疾病的进展如下。 高度近视:收集了534个样本。经过第一次、第二次和第三次筛选,共有 156 个阳性标记通过。单独分型的结果是,获得了26个阳性标记。在白塞病候选区域周围进行 SNP 分型:收集了 427 个样本。完成第一次、第二次、第三次MS筛查和个体基因分型,获得11个阳性标志物。 SNP分型在每个候选区域的周围进行。晶格变性:收集了397个样本。在第一次筛选中,我们发现 2851 个标记物具有显着关联。高血压:收集了 508 个样本。 MS筛选完成,获得135个阳性标志物。然后进行个人打字,并通过了 55 个标记。 SNP 基因分型现已进行。青光眼:收集了 192 个样本。使用 138 个样本进行第一次筛选,获得 13.8% 的阳性标志物。第二个屏幕现在正在执行。同时,使用 GeneChip 进行 SNP 分型也在进行中。
项目成果
期刊论文数量(123)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Exclusion of the transforming growth factor-β as a candidate gene for high myopia in the Japanese.
排除转化生长因子-β作为日本人高度近视的候选基因。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Nomura K;Murakami K;Shozu M;Nakama T;Yui N;Inoue M.;Hayashi T
- 通讯作者:Hayashi T
近視の分子遺伝学
近视的分子遗传学
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Masai H;Taniyama C;Ogino K;Matsui E;Kakusho N;Matsumoto S.;Kim JM;Ishii A;Tanaka T;Kobayashi T;Tamai K;Ohtani K;Arai K;水木信久
- 通讯作者:水木信久
Drug induced hypersensitivity syndrome due to cyanamide associated with multiple reactivation of human herpesviruses
与人类疱疹病毒多次再激活相关的氰胺引起的药物过敏综合征
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:福田治久;今中雄一;廣瀬昌博;林田賢史.;Mitani N
- 通讯作者:Mitani N
Single nucleotide polymorphisms of Ficolin 2 gene in Behcet's disease
- DOI:10.1016/j.jdermsci.2006.05.010
- 发表时间:2006-09-01
- 期刊:
- 影响因子:4.6
- 作者:Chen, Xixue;Katoh, Yasunobu;Mizuki, Nobuhisa
- 通讯作者:Mizuki, Nobuhisa
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MIZUKI Nobuhisa其他文献
MIZUKI Nobuhisa的其他文献
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{{ truncateString('MIZUKI Nobuhisa', 18)}}的其他基金
whole-exome sequencing analysis of uveitis diseases
葡萄膜炎疾病的全外显子组测序分析
- 批准号:
20H03843 - 财政年份:2020
- 资助金额:
$ 30.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Whole-exome sequencing in families with late-onset developmental glaucoma
晚发性发育性青光眼家族的全外显子组测序
- 批准号:
26293077 - 财政年份:2014
- 资助金额:
$ 30.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of risk factors associated with non-response to infliximab treatment for Behcet's disease
英夫利昔单抗治疗白塞病无反应的危险因素分析
- 批准号:
23659815 - 财政年份:2011
- 资助金额:
$ 30.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Genetic association study of Behcet's disease in multiple ethnic groups
白塞氏病多民族遗传关联研究
- 批准号:
22390065 - 财政年份:2010
- 资助金额:
$ 30.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Genome-wide microsatellite mapping of multi-factorial ocular diseases.
多因素眼部疾病的全基因组微卫星图谱。
- 批准号:
14370562 - 财政年份:2002
- 资助金额:
$ 30.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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