A start-up project for the miltiple-scale connectomics project

多重规模连接组学项目的启动项目

• 批准号: 16H06916
• 负责人: 下野 昌宣
• 金额: $ 1.91万
• 依托单位: Osaka University (2017)Kyoto University (2016)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-08-26 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16H06916/
• 关键词: ネットワーク; データ駆動科学; 脳; 神経; マルチスケール; ダイナミクス; シミュレーション; コネクトーム; インフォマティクス; システム生物学; グラフ; 因果性; 局所回路; 領域間相互作用; モデリング

本研究プロジェクトは、挑戦的萌芽研究の合格に伴い最終年を残しての終了となる。本研究期間での主だった成果は以下の3点である：1. 脳の広域ネットワーク上での電気伝達現象に関する解析を進めてきた。その際、脳広域の構造接続データ、脳広域で計測したECoG データ、ニューロンのSpike データらを有機的に結びつけるスキームを構築し、その伝搬速度が約1.0-1.5m/sである事、電気伝搬は最短パスを95%程度の割合で用いている事などを明らかとした。2. ミクロ回路側でのネットワーク解析の研究も前進している。これまで電気生理学実験でのin vitro と in vivo のデータを対象としていた手法を、in vivo の蛍光イメージングデータにも適用して、行動パラメーターやマクロな接続構造との比較を行った[Nakamura, Shimono, 2017]。3. ミクロ回路のシミュレーションにおいて、多ニューロンのトポロジーもしくは皮質の層構造などの拘束条件を自然と与えた上で、発火率が対数正規(log-normal)分布に従う様なダイナミクスから非自明な他の動的特性が生じるメカニズムの解明を行った。1の成果は、国際学会であるNetSci2017学会においてfeatured talkとしての発表も行った。1, 2の成果は、国内学会、日本神経科学学会でのセッションを受け持ち口答発表を行い、国際学会OCNSでも発表を行った。また、1の成果は論文としてまとまり、bioArxivに公開した上で査読を進めており[Shimono, Hatano, 2017]、2,3の成果の論文を準備中である。総じて、数理シミュレーションの基盤の構築から非自明な発見への道筋が付けられた。

This study is aimed at identifying and identifying the most appropriate and appropriate research methods for embryonic development. The main results of this study are as follows: 1. The analysis of the electrical phenomena in the field of electricity generation is carried out. In addition, the structure of the distribution domain is connected with the structure of the distribution domain, the measurement of the distribution domain is ECoG data, the Spike data of the distribution domain is organic, the transmission speed of the distribution domain is about 1.0-1.5m/s, and the transmission speed of the distribution domain is about 95%. 2. The research on the analysis of the loop side of the circuit is progressing. This is a comparison of electrical physiology in vitro and in vivo [Nakamura, Shimono, 2017]. 3. The structure of cortical layer is constrained by natural and inverse conditions, and the fire rate is log-normal distribution. NetSci2017 Academy features talk and presentation. The achievements of 1 and 2 are supported by the development of the national society, the Japanese society of neuroscience, and the international society OCNS. The results of 1, 2 and 3 papers are in preparation.[Shimono, Hatano, 2017] The construction of the base plate of the complex and mathematical model is not obvious, and the road reinforcement is not easy to be realized.

项目成果

Micro-connectomics with cognitive task selectivity

具有认知任务选择性的微连接组学

• 发表时间: 2017
• 作者: Akihiro Nakamura;Masanori Shimono
• 通讯作者: Masanori Shimono

"When" in Macro-connectome and Communicability

宏观连接组和沟通性中的“何时”

• 发表时间: 2017
• 作者: Akihiro Nakamura;Masanori Shimono;Masanori Shimono
• 通讯作者: Masanori Shimono

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2

• DOI: 10.1186/s12868-017-0371-2
• 发表时间: 2017-08-18
• 期刊: BMC Neuroscience
• 影响因子: 2.4
• 作者: Rubchinsky LL;Ahn S;Klijn W;Cumming B;Yates S;Karakasis V;Peyser A;Woodman M;Diaz-Pier S;Deraeve J;Vassena E;Alexander W;Beeman D;Kudela P;Boatman-Reich D;Anderson WS;Luque NR;Naveros F;Carrillo RR;Ros E;Arleo A;Huth J;Ichinose K;Park J;Kawai Y;Suzuki J;Mori H;Asada M;Oprisan SA;Dave AI;Babaie T;Robinson P;Tabas A;Andermann M;Rupp A;Balaguer-Ballester E;Lindén H;Christensen RK;Nakamura M;Barkat TR;Tosi Z;Beggs J;Lonardoni D;Boi F;Di Marco S;Maccione A;Berdondini L;Jędrzejewska-Szmek J;Dorman DB;Blackwell KT;Bauermeister C;Keren H;Braun J;Dornas JV;Mavritsaki E;Aldrovandi S;Bridger E;Lim S;Brunel N;Buchin A;Kerr CC;Chizhov A;Huberfeld G;Miles R;Gutkin B;Spencer MJ;Meffin H;Grayden DB;Burkitt AN;Davey CE;Tao L;Tiruvadi V;Ali R;Mayberg H;Butera R;Gunay C;Lamb D;Calabrese RL;Doloc-Mihu A;López-Madrona VJ;Matias FS;Pereda E;Mirasso CR;Canals S;Geminiani A;Pedrocchi A;D’Angelo E;Casellato C;Chauhan A;Soman K;Srinivasa Chakravarthy V;Muddapu VR;Chuang CC;Chen NY;Bayati M;Melchior J;Wiskott L;Azizi AH;Diba K;Cheng S;Smirnova EY;Yakimova EG;Chizhov AV;Chen NY;Shih CT;Florescu D;Coca D;Courtiol J;Jirsa VK;Covolan RJ;Teleńczuk B;Kempter R;Curio G;Destexhe A;Parker J;Klishko AN;Prilutsky BI;Cymbalyuk G;Franke F;Hierlemann A;da Silveira RA;Casali S;Masoli S;Rizza M;Rizza MF;Masoli S;Sun Y;Wong W;Farzan F;Blumberger DM;Daskalakis ZJ;Popovych S;Viswanathan S;Rosjat N;Grefkes C;Daun S;Gentiletti D;Suffczynski P;Gnatkovski V;De Curtis M;Lee H;Paik SB;Choi W;Jang J;Park Y;Song JH;Song M;Pallarés V;Gilson M;Kühn S;Insabato A;Deco G;Glomb K;Ponce-Alvarez A;Ritter P;Gilson M;Campo AT;Thiele A;Deeba F;Robinson PA;van Albada SJ;Rowley A;Hopkins M;Schmidt M;Stokes AB;Lester DR;Furber S;Diesmann M;Barri A;Wiechert MT;DiGregorio DA;Dimitrov AG;Vich C;Berg RW;Guillamon A;Ditlevsen S;Cazé RD;Girard B;Doncieux S;Doyon N;Boahen F;Desrosiers P;Laurence E;Doyon N;Dubé LJ;Eleonora R;Durstewitz D;Schmidt D;Mäki-Marttunen T;Krull F;Bettella F;Metzner C;Devor A;Djurovic S;Dale AM;Andreassen OA;Einevoll GT;Næss S;Ness TV;Halnes G;Halgren E;Halnes G;Mäki-Marttunen T;Pettersen KH;Andreassen OA;Sætra MJ;Hagen E;Schiffer A;Grzymisch A;Persike M;Ernst U;Harnack D;Ernst UA;Tomen N;Zucca S;Pasquale V;Pica G;Molano-Mazón M;Chiappalone M;Panzeri S;Fellin T;Oie KS;Boothe DL;Crone JC;Yu AB;Felton MA Jr;Zulfiqar I;Moerel M;De Weerd P;Formisano E;Boothe DL;Crone JC;Felton MA Jr;Oie K;Franaszczuk P;Diggelmann R;Fiscella M;Hierlemann A;Franke F;Guarino D;Antolík J;Davison AP;Frègnac Y;Etienne BX;Frohlich F;Lefebvre J;Marcos E;Mattia M;Genovesio A;Fedorov LA;Dijkstra TM;Sting L;Hock H;Giese MA;Buhry L;Langlet C;Giovannini F;Verbist C;Salvadé S;Giugliano M;Henderson JA;Wernecke H;Sándor B;Gros C;Voges N;Dabrovska P;Riehle A;Brochier T;Grün S;Gu Y;Gong P;Dumont G;Novikov NA;Gutkin BS;Tewatia P;Eriksson O;Kramer A;Santos J;Jauhiainen A;Kotaleski JH;Belić JJ;Kumar A;Kotaleski JH;Shimono M;Hatano N;Ahmad S;Cui Y;Hawkins J;Senk J;Korvasová K;Tetzlaff T;Helias M;Kühn T;Denker M;Mana P;Grün S;Dahmen D;Schuecker J;Goedeke S;Keup C;Goedeke S;Heuer K;Bakker R;Tiesinga P;Toro R;Qin W;Hadjinicolaou A;Grayden DB;Ibbotson MR;Kameneva T;Lytton WW;Mulugeta L;Drach A;Myers JG Jr;Horner M;Vadigepalli R;Morrison T;Walton M;Steele M;Anthony Hunt C;Tam N;Amaducci R;Muñiz C;Reyes-Sánchez M;Rodríguez FB;Varona P;Cronin JT;Hennig MH;Iavarone E;Yi J;Shi Y;Zandt BJ;Van Geit W;Rössert C;Markram H;Hill S;O’Reilly C;Iavarone E;Shi Y;Perin R;Lu H;Zandt BJ;Bryson A;Rössert C;Hadrava M;Hlinka J;Hosaka R;Olenik M;Houghton C;Iannella N;Launey T;Kameneva T;Kotsakidis R;Meffin H;Soriano J;Kubo T;Inoue T;Kida H;Yamakawa T;Suzuki M;Ikeda K;Abbasi S;Hudson AE;Heck DH;Jaeger D;Lee J;Abbasi S;Janušonis S;Saggio ML;Spiegler A;Stacey WC;Bernard C;Lillo D;Bernard C;Petkoski S;Spiegler A;Drakesmith M;Jones DK;Zadeh AS;Kambhampati C;Karbowski J;Kaya ZG;Lakretz Y;Treves A;Li LW;Lizier J;Kerr CC;Masquelier T;Kheradpisheh SR;Kim H;Kim CS;Marakshina JA;Vartanov AV;Neklyudova AA;Kozlovskiy SA;Kiselnikov AA;Taniguchi K;Kitano K;Schmitt O;Lessmann F;Schwanke S;Eipert P;Meinhardt J;Beier J;Kadir K;Karnitzki A;Sellner L;Klünker AC;Kuch L;Ruß F;Jenssen J;Wree A;Sanz-Leon P;Knock SA;Chien SC;Maess B;Knösche TR;Cohen CC;Popovic MA;Klooster J;Kole MH;Roberts EA;Kopell NJ;Kepple D;Giaffar H;Rinberg D;Koulakov A;Forlim CG;Klock L;Bächle J;Stoll L;Giemsa P;Fuchs M;Schoofs N;Montag C;Gallinat J;Lee RX;Stephens GJ;Kuhn B;Tauffer L;Isope P;Inoue K;Ohmura Y;Yonekura S;Kuniyoshi Y;Jang HJ;Kwag J;de Kamps M;Lai YM;dos Santos F;Lam KP;Andras P;Imperatore J;Helms J;Tompa T;Lavin A;Inkpen FH;Ashby MC;Lepora NF;Shifman AR;Lewis JE;Zhang Z;Feng Y;Tetzlaff C;Kulvicius T;Li Y;Pena RF;Bernardi D;Roque AC;Lindner B;Bernardi D;Vellmer S;Saudargiene A;Maninen T;Havela R;Linne ML;Powanwe A;Longtin A;Naveros F;Garrido JA;Graham JW;Dura-Bernal S;Angulo SL;Neymotin SA;Antic SD
• 通讯作者: Antic SD

Electrical propagation on Cortical Connectome and Communicability

皮质连接组的电传播和沟通性

• 发表时间: 2017
• 作者: Masanori Shimono;Naomichi Hatano
• 通讯作者: Naomichi Hatano

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3

• DOI: 10.1186/s12868-017-0372-1
• 发表时间: 2017-08-18
• 期刊: BMC Neuroscience
• 影响因子: 2.4
• 作者: Newton AJ;Seidenstein AH;McDougal RA;Pérez-Cervera A;Huguet G;M-Seara T;Haimerl C;Angulo-Garcia D;Torcini A;Cossart R;Malvache A;Skiker K;Maouene M;Ragognetti G;Lorusso L;Viggiano A;Marcelli A;Senatore R;Parziale A;Stramaglia S;Pellicoro M;Angelini L;Amico E;Aerts H;Cortés J;Laureys S;Marinazzo D;Stramaglia S;Bassez I;Faes L;Almgren H;Razi A;Van de Steen F;Krebs R;Aerts H;Kanari L;Dlotko P;Scolamiero M;Levi R;Shillcock J;de Kock CP;Hess K;Markram H;Ly C;Marsat G;Gillespie T;Sandström M;Abrams M;Grethe JS;Martone M;De Gernier R;Solinas S;Rössert C;Haelterman M;Massar S;Pasquale V;Pastore VP;Martinoia S;Massobrio P;Capone C;Tort-Colet N;Sanchez-Vives MV;Mattia M;Almasi A;Cloherty SL;Grayden DB;Wong YT;Ibbotson MR;Meffin H;Prince LY;Tsaneva-Atanasova K;Mellor JR;Mazzoni A;Rosa M;Carpaneto J;Romito LM;Priori A;Micera S;Migliore R;Lupascu CA;Franchina F;Bologna LL;Romani A;Saray S;Van Geit W;Káli S;Thomson A;Mercer A;Lange S;Falck J;Muller E;Schürmann F;Todorov D;Capps R;Barnett W;Molkov Y;Devalle F;Pazó D;Montbrió E;Mochol G;Azab H;Hayden BY;Moreno-Bote R;Balasubramani PP;Chakravarthy SV;Muddapu VR;Gheorghiu MD;Mimica B;Withlock J;Mureșan RC;Zick JL;Schultz K;Blackman RK;Chafee MV;Netoff TI;Roberts N;Nagaraj V;Lamperski A;Netoff TI;Grado LL;Johnson MD;Darrow DP;Lonardoni D;Amin H;Di Marco S;Maccione A;Berdondini L;Nieus T;Stimberg M;Goodman DF;Nowotny T;Koren V;Dragoi V;Obermayer K;Castro S;Fernandez M;El-Deredy W;Xu K;Maidana JP;Orio P;Chen W;Hepburn I;Casalegno F;Devresse A;Ovcharenko A;Pereira F;Delalondre F;De Schutter E;Bratby P;Gallimore AR;Klingbeil G;Zamora C;Zang Y;Crotty P;Palmerduca E;Antonietti A;Casellato C;Erö C;D’Angelo E;Gewaltig MO;Pedrocchi A;Bytschok I;Dold D;Schemmel J;Meier K;Petrovici MA;Shen HA;Surace SC;Pfister JP;Lefebvre B;Marre O;Yger P;Papoutsi A;Park J;Ash R;Smirnakis S;Poirazi P;Felix RA;Dimitrov AG;Portfors C;Daun S;Toth TI;Jędrzejewska-Szmek J;Kabbani N;Blackwel KT;Moezzi B;Schaworonkow N;Plogmacher L;Goldsworthy MR;Hordacre B;McDonnell MD;Iannella N;Ridding MC;Triesch J;Maex R;Safaryan K;Steuber V;Tang R;Tang YY;Verveyko DV;Brazhe AR;Verisokin AY;Postnov DE;Günay C;Panuccio G;Giugliano M;Prinz AA;Varona P;Rabinovich MI;Denham J;Ranner T;Cohen N;Reva M;Rebola N;Kirizs T;Nusser Z;DiGregorio D;Mavritsaki E;Rentzelas P;Ukani NH;Tomkins A;Yeh CH;Bruning W;Fenichel AL;Zhou Y;Huang YC;Florescu D;Ortiz CL;Richmond P;Lo CC;Coca D;Chiang AS;Lazar AA;Moezzi B;Creaser JL;Lin C;Ashwin P;Brown JT;Ridler T;Levenstein D;Watson BO;Buzsáki G;Rinzel J;Curtu R;Nguyen A;Assadzadeh S;Robinson PA;Sanz-Leon P;Forlim CG;de Almeida LO;Pinto RD;Rodríguez FB;Lareo Á;Forlim CG;Rodríguez FB;Montero A;Mosqueiro T;Huerta R;Rodriguez FB;Changoluisa V;Rodriguez FB;Cordeiro VL;Ceballos CC;Kamiji NL;Roque AC;Lytton WW;Knox A;Rosenthal JJ;Daun S;Popovych S;Liu L;Wang BA;Tóth TI;Grefkes C;Fink GR;Rosjat N;Perez-Trujillo A;Espinal A;Sotelo-Figueroa MA;Cruz-Aceves I;Rostro-Gonzalez H;Zapotocky M;Hoskovcová M;Kopecká J;Ulmanová O;Růžička E;Gärtner M;Duvarci S;Roeper J;Schneider G;Albert S;Schmack K;Remme M;Schreiber S;Migliore M;Lupascu CA;Bologna LL;Antonel SM;Courcol JD;Schürmann F;Çelikok SU;Navarro-López EM;Şengör NS;Elibol R;Sengor NS;Özdemir MY;Li T;Arleo A;Sheynikhovich D;Nakamura A;Shimono M;Song Y;Park S;Choi I;Jeong J;Shin HS;Sadeh S;Gleeson P;Angus Silver R;Chatzikalymniou AP;Skinner FK;Sanchez-Rodriguez LM;Sotero RC;Hertäg L;Mackwood O;Sprekeler H;Puhlmann S;Weber SN;Higgins D;Naumann LB;Weber SN;Iyer R;Mihalas S;Ticcinelli V;Stankovski T;McClintock PV;Stefanovska A;Janjić P;Solev D;Seifert G;Kocarev L;Steinhäuser C;Salmasi M;Glasauer S;Stemmler M;Zhang D;Zhang C;Stepanyants A;Goncharenko J;Kros L;Davey N;de Zeeuw C;Hoebeek F;Sinha A;Adams R;Schmuker M;Psarrou M;Schilstra M;Torben-Nielsen B;Metzner C;Schweikard A;Mäki-Marttunen T;Zurowski B;Marinazzo D;Faes L;Stramaglia S;Jordan HO;Stringer SM;Gajewska-Dendek E;Suffczyński P;Tam N;Zouridakis G;Pollonini L;Tang YY;Asl MM;Valizadeh A;Tass PA;Nold A;Fan W;Konrad S;Endle H;Vogt J;Tchumatchenko T;Herpich J;Tetzlaff C;Luboeinski J;Nachstedt T;Ciba M;Bahmer A;Thielemann C;Kuebler ES;Tauskela JS;Thivierge JP;Bakker R;García-Amado M;Evangelio M;Clascá F;Tiesinga P;Buckley CL;Toyoizumi T;Dubreuil AM;Monasson R;Treves A;Spalla D;Rosay S;Kleberg FI;Wong W;de Oliveira Floriano B;Matsuo T;Uchida T;Dibenedetto D;Uludağ K;Goodarzinick A;Schmidt M;Hilgetag CC;Diesmann M;van Albada SJ;Fauth M;van Rossum M;Reyes-Sánchez M;Amaducci R;Muñiz C;Varona P;Elices I;Arroyo D;Levi R;Cohen B;Chow C;Vattikuti S;Bertolotti E;Burioni R;di Volo M;Vezzani A;Menzat B;Vogels TP;Wagatsuma N;Saha S;Kapoor R;Kerr R;Wagner J;del Molino LC;Yang GR;Mejias JF;Wang XJ;Song H;Goodliffe J;Luebke J;Weaver CM;Thomas J;Sinha N;Shaju N;Maszczyk T;Jin J;Cash SS;Dauwels J;Brandon Westover M;Karimian M;Moerel M;De Weerd P;Burwick T;Westra RL;Abeysuriya R;Hadida J;Sotiropoulos S;Jbabdi S;Woolrich M;Bensmail C;Wrobel B;Zhou X;Ji Z;Liu X;Xia Y;Wu S;Wang X;Zhang M;Wu S;Ofer N;Shefi O;Yaari G;Carnevale T;Majumdar A;Sivagnanam S;Yoshimoto K;Smirnova EY;Amakhin DV;Malkin SL;Zaitsev AV;Chizhov AV;Zaleshina M;Zaleshin A;Barranca VJ;Zhu G;Skilling QM;Maruyama D;Ognjanovski N;Aton SJ;Zochowski M;Wu J;Aton S;Rich S;Booth V;Budak M;Dura-Bernal S;Neymotin SA;Suter BA;Shepherd GM;Felton MA Jr;Yu AB;Boothe DL;Oie KS;Franaszczuk PJ;Shuvaev SA;Başerdem B;Zador A;Koulakov AA;López-Madrona VJ;Pereda E;Mirasso CR;Canals S;Masoli S;Rongala UB;Mazzoni A;Spanne A;Jorntell H;Oddo CM;Vartanov AV;Neklyudova AK;Kozlovskiy SA;Kiselnikov AA;Marakshina JA;Teleńczuk M;Teleńczuk B;Destexhe A;Kuokkanen PT;Kraemer A;McColgan T;Carr CE;Kempter R
• 通讯作者: Kempter R